Mitochondrial DNA transfer between malignant cells and T lymphocytes shapes the cancer-immunity dialogue
Nonmutated mitochondrial DNA (mtDNA) from T lymphocytes can be incorporated into cancer cells bearing mutated mtDNA to repair their bioenergetic deficiency. However, a recent paper by Ikeda et al. indicates that mutated mtDNA from malignant cells can also be transferred into tumor-infiltrating T lym...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | OncoImmunology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/2162402X.2025.2512109 |
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| _version_ | 1850108388373954560 |
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| author | Liwei Zhao Peng Liu Oliver Kepp Guido Kroemer |
| author_facet | Liwei Zhao Peng Liu Oliver Kepp Guido Kroemer |
| author_sort | Liwei Zhao |
| collection | DOAJ |
| description | Nonmutated mitochondrial DNA (mtDNA) from T lymphocytes can be incorporated into cancer cells bearing mutated mtDNA to repair their bioenergetic deficiency. However, a recent paper by Ikeda et al. indicates that mutated mtDNA from malignant cells can also be transferred into tumor-infiltrating T lymphocytes to subvert their function in cancer immunosurveillance. |
| format | Article |
| id | doaj-art-580272f2c9eb4871a719a8a47776918d |
| institution | OA Journals |
| issn | 2162-402X |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | OncoImmunology |
| spelling | doaj-art-580272f2c9eb4871a719a8a47776918d2025-08-20T02:38:22ZengTaylor & Francis GroupOncoImmunology2162-402X2025-12-0114110.1080/2162402X.2025.2512109Mitochondrial DNA transfer between malignant cells and T lymphocytes shapes the cancer-immunity dialogueLiwei Zhao0Peng Liu1Oliver Kepp2Guido Kroemer3Equipe labellisée par La Ligue contre le cancer, Université de Paris Cité, Sorbonne Université, INSERM UMR1138, Centre de Recherche des Cordeliers, Paris, FranceEquipe labellisée par La Ligue contre le cancer, Université de Paris Cité, Sorbonne Université, INSERM UMR1138, Centre de Recherche des Cordeliers, Paris, FranceEquipe labellisée par La Ligue contre le cancer, Université de Paris Cité, Sorbonne Université, INSERM UMR1138, Centre de Recherche des Cordeliers, Paris, FranceEquipe labellisée par La Ligue contre le cancer, Université de Paris Cité, Sorbonne Université, INSERM UMR1138, Centre de Recherche des Cordeliers, Paris, FranceNonmutated mitochondrial DNA (mtDNA) from T lymphocytes can be incorporated into cancer cells bearing mutated mtDNA to repair their bioenergetic deficiency. However, a recent paper by Ikeda et al. indicates that mutated mtDNA from malignant cells can also be transferred into tumor-infiltrating T lymphocytes to subvert their function in cancer immunosurveillance.https://www.tandfonline.com/doi/10.1080/2162402X.2025.2512109ImmunotherapyImmune checkpoint inhibitionimmunosuppression |
| spellingShingle | Liwei Zhao Peng Liu Oliver Kepp Guido Kroemer Mitochondrial DNA transfer between malignant cells and T lymphocytes shapes the cancer-immunity dialogue OncoImmunology Immunotherapy Immune checkpoint inhibition immunosuppression |
| title | Mitochondrial DNA transfer between malignant cells and T lymphocytes shapes the cancer-immunity dialogue |
| title_full | Mitochondrial DNA transfer between malignant cells and T lymphocytes shapes the cancer-immunity dialogue |
| title_fullStr | Mitochondrial DNA transfer between malignant cells and T lymphocytes shapes the cancer-immunity dialogue |
| title_full_unstemmed | Mitochondrial DNA transfer between malignant cells and T lymphocytes shapes the cancer-immunity dialogue |
| title_short | Mitochondrial DNA transfer between malignant cells and T lymphocytes shapes the cancer-immunity dialogue |
| title_sort | mitochondrial dna transfer between malignant cells and t lymphocytes shapes the cancer immunity dialogue |
| topic | Immunotherapy Immune checkpoint inhibition immunosuppression |
| url | https://www.tandfonline.com/doi/10.1080/2162402X.2025.2512109 |
| work_keys_str_mv | AT liweizhao mitochondrialdnatransferbetweenmalignantcellsandtlymphocytesshapesthecancerimmunitydialogue AT pengliu mitochondrialdnatransferbetweenmalignantcellsandtlymphocytesshapesthecancerimmunitydialogue AT oliverkepp mitochondrialdnatransferbetweenmalignantcellsandtlymphocytesshapesthecancerimmunitydialogue AT guidokroemer mitochondrialdnatransferbetweenmalignantcellsandtlymphocytesshapesthecancerimmunitydialogue |