Knockout of Bmal1 in dopaminergic neurons induces ADHD-like symptoms via hyperactive dopamine signaling in male mice

Knockout of Bmal1 in dopaminergic neurons induces ADHD-like symptoms via hyperactive dopamine signaling in male mice

Abstract Background The central circadian clock coordinates daily oscillations in physiology, metabolism and behavior. Disruptions to core circadian clock genes not only perturb sleep-wake rhythms but also contribute to psychiatric disorders. While dopaminergic dysfunction is strongly associated wit...

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Bibliographic Details
Main Authors: Yichun Zhang, Xin Li, Yong Liu, Xiangyu Li, Dengfeng Liu, Qingyun Han, Xiran Liu, Xuyi Wang, Jia-Da Li, Suixin Deng
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Behavioral and Brain Functions
Subjects:
Circadian genes
BMAL1
ADHD
Dopamine
Dorsal striatum
Online Access:https://doi.org/10.1186/s12993-025-00287-w
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