Effect of Combined Oral Contraceptive on Flap Surgery in Female Rat Model
Combined oral contraceptives (COCs) are said to have a negative effect on flap surgery's outcomes due to their adverse effects on tissue perfusion, managing inflammation, and oxidative stress. This study aimed to investigate the effects of COCs use on flap survival in a female rat model. In th...
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Universidad del Zulia
2025-05-01
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| Series: | Revista Científica |
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| Online Access: | https://produccioncientificaluz.org/index.php/cientifica/article/view/43840 |
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| author | Abdulkadir Calavul Burhan Özalp Serdar Menekşe |
| author_facet | Abdulkadir Calavul Burhan Özalp Serdar Menekşe |
| author_sort | Abdulkadir Calavul |
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Combined oral contraceptives (COCs) are said to have a negative effect on flap surgery's outcomes due to their adverse effects on tissue perfusion, managing inflammation, and oxidative stress. This study aimed to investigate the effects of COCs use on flap survival in a female rat model. In this randomized controlled experimental study, a total of 20 female Wistar Albino rats were divided into control and COC groups (n=10/group). The COC group received Desolett® (Desogestrel 0.15 mg, Ethinyl estradiol 0.03 mg) orogastrically for three weeks. The McFarlane flap model was surgically implemented, and flap survival was evaluated using digital planimetry. Histopathological and biochemical analyses were performed during the postoperative period. The flap survival rate in the COC group was significantly lower compared to the control group (74.4 vs 83.7%, P=0.012). Furthermore, the COC group demonstrated a higher necrotic area ratio (25.7 vs 18.4%, P=0.015) and more severe inflammatory cell infiltration (2.4 ± 0.5 vs 1.8 ± 0.4, P=0.011). Biochemical analyses revealed higher malondialdehyde (MDA) levels (4.86 ± 0.72 vs 3.24 ± 0.58 nmol/mg, P=0.008) and lower superoxide dismutase (SOD) activity (14.2 ± 2.1 vs 18.5 ± 2.4 U/mg, P=0.012) in the COC group. Using COCs reduces the chances of a successful flap surgery and promotes the chances of complications arising owing to oxidative stress, inflammation and impairment of tissue perfusion. These observations merit caution while planning flap surgery for COCs users and a recommendation for a brief halt in the usage of COCs should be made. The results underscore the importance of understanding the potential implications of COCs use in surgical planning and postoperative care management.
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| format | Article |
| id | doaj-art-57fd4eb7eec947168faf5d675180a4e8 |
| institution | Kabale University |
| issn | 0798-2259 2521-9715 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Universidad del Zulia |
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| series | Revista Científica |
| spelling | doaj-art-57fd4eb7eec947168faf5d675180a4e82025-08-20T03:52:29ZengUniversidad del ZuliaRevista Científica0798-22592521-97152025-05-0135210.52973/rcfcv-e35611Effect of Combined Oral Contraceptive on Flap Surgery in Female Rat ModelAbdulkadir Calavul0Burhan Özalp1Serdar Menekşe2Health Sciences University, Eskişehir City Health Practice and Research Center, Department of Plastic Surgery, Eskişehir, TürkiyeBurhan Özalp Private Clinic, TürkiyeAdana Seyhan State Hospital, Department of Plastic Surgery, Seyhan/Adana, Türkiye. Combined oral contraceptives (COCs) are said to have a negative effect on flap surgery's outcomes due to their adverse effects on tissue perfusion, managing inflammation, and oxidative stress. This study aimed to investigate the effects of COCs use on flap survival in a female rat model. In this randomized controlled experimental study, a total of 20 female Wistar Albino rats were divided into control and COC groups (n=10/group). The COC group received Desolett® (Desogestrel 0.15 mg, Ethinyl estradiol 0.03 mg) orogastrically for three weeks. The McFarlane flap model was surgically implemented, and flap survival was evaluated using digital planimetry. Histopathological and biochemical analyses were performed during the postoperative period. The flap survival rate in the COC group was significantly lower compared to the control group (74.4 vs 83.7%, P=0.012). Furthermore, the COC group demonstrated a higher necrotic area ratio (25.7 vs 18.4%, P=0.015) and more severe inflammatory cell infiltration (2.4 ± 0.5 vs 1.8 ± 0.4, P=0.011). Biochemical analyses revealed higher malondialdehyde (MDA) levels (4.86 ± 0.72 vs 3.24 ± 0.58 nmol/mg, P=0.008) and lower superoxide dismutase (SOD) activity (14.2 ± 2.1 vs 18.5 ± 2.4 U/mg, P=0.012) in the COC group. Using COCs reduces the chances of a successful flap surgery and promotes the chances of complications arising owing to oxidative stress, inflammation and impairment of tissue perfusion. These observations merit caution while planning flap surgery for COCs users and a recommendation for a brief halt in the usage of COCs should be made. The results underscore the importance of understanding the potential implications of COCs use in surgical planning and postoperative care management. https://produccioncientificaluz.org/index.php/cientifica/article/view/43840Combined oral contraceptivesflap surgeryoxidative stressinflammationflap survival |
| spellingShingle | Abdulkadir Calavul Burhan Özalp Serdar Menekşe Effect of Combined Oral Contraceptive on Flap Surgery in Female Rat Model Revista Científica Combined oral contraceptives flap surgery oxidative stress inflammation flap survival |
| title | Effect of Combined Oral Contraceptive on Flap Surgery in Female Rat Model |
| title_full | Effect of Combined Oral Contraceptive on Flap Surgery in Female Rat Model |
| title_fullStr | Effect of Combined Oral Contraceptive on Flap Surgery in Female Rat Model |
| title_full_unstemmed | Effect of Combined Oral Contraceptive on Flap Surgery in Female Rat Model |
| title_short | Effect of Combined Oral Contraceptive on Flap Surgery in Female Rat Model |
| title_sort | effect of combined oral contraceptive on flap surgery in female rat model |
| topic | Combined oral contraceptives flap surgery oxidative stress inflammation flap survival |
| url | https://produccioncientificaluz.org/index.php/cientifica/article/view/43840 |
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