MGP regulates the adipogenic differentiation of mesenchymal stem cells in osteoporosis via the Ca2+/CaMKII/RIP140/FABP3 axis

MGP regulates the adipogenic differentiation of mesenchymal stem cells in osteoporosis via the Ca2+/CaMKII/RIP140/FABP3 axis

Abstract The dysregulation of bone marrow mesenchymal stem cells (BM-MSCs) is crucial in the pathogenesis of osteoporosis, and adipogenic differentiation of BM-MSCs is considered an essential factor in this process. However, the mechanisms underlying the regulation of MSC adipogenic differentiation...

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Main Authors: Xinglang Wang, Yunhui Zhang, Chenhao Xu, Quanfeng Li, Pengfei Ji, Huatao Liu, Yibin Zhang, Jiahao Jin, Zihao Yuan, Miao Yuan, Pei Feng, Yanfeng Wu, Wenjie Liu, Huiyong Shen, Peng Wang
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02472-2
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