Influence of fused deposition modelling printing parameters on tablet disintegration times: a design of experiments study
Despite the importance of process parameters in the printing of solid dosage forms using fused deposition modelling (FDM) technology, the field is still poorly explored. A design of experiment study was conducted to understand the complete set of process parameters of a custom developed FDM 3D pri...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2023-09-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2023-0026 |
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| author | Kreft Klemen Stanić Tijana Perhavec Petra Dreu Rok Lavrič Zoran |
| author_facet | Kreft Klemen Stanić Tijana Perhavec Petra Dreu Rok Lavrič Zoran |
| author_sort | Kreft Klemen |
| collection | DOAJ |
| description | Despite the importance of process parameters in the printing of solid dosage forms using fused deposition modelling (FDM) technology, the field is still poorly explored. A design of experiment study was conducted to understand the complete set of process parameters of a custom developed FDM 3D printer and their influence on tablet disintegration time. Nine settings in the Simplify 3D printing process design software were evaluated with further experimental investigation conducted on the influence of infill percentage, infill pattern, nozzle diameter, and layer height. The percentage of infill was identified as the most impactful parameter, as increasing it parabolically affected the increase of disintegration time. Furthermore, a larger nozzle diameter prolonged tablet disintegration, since thicker extruded strands are generated through wider nozzles during the printing process. Three infill patterns were selected for in-depth analysis, demonstrating the clear importance of the geometry of the internal structure to resist mechanical stress during the disintegration test. Lastly, layer height did not influence the disintegration time. A statistical model with accurate fit (R2 = 0.928) and predictability (Q2 = 0.847) was created. In addition, only the infill pattern and layer height influenced both the uniformity of mass and uniformity of the disintegration time, which demonstrates the robustness of the printing process. |
| format | Article |
| id | doaj-art-57f8a462c13c45e89e3b8d4bb10a425c |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-57f8a462c13c45e89e3b8d4bb10a425c2025-02-03T02:26:14ZengSciendoActa Pharmaceutica1846-95582023-09-0173340542210.2478/acph-2023-0026Influence of fused deposition modelling printing parameters on tablet disintegration times: a design of experiments studyKreft Klemen0Stanić Tijana1Perhavec Petra2Dreu Rok3Lavrič Zoran4University of Ljubljana, Faculty of Pharmacy, 1000Ljubljana, SloveniaLek Pharmaceuticals d.d., a Sandoz Company, 1000Ljubljana, SloveniaLek Pharmaceuticals d.d., a Sandoz Company, 1000Ljubljana, SloveniaUniversity of Ljubljana, Faculty of Pharmacy, 1000Ljubljana, SloveniaUniversity of Ljubljana, Faculty of Pharmacy, 1000Ljubljana, SloveniaDespite the importance of process parameters in the printing of solid dosage forms using fused deposition modelling (FDM) technology, the field is still poorly explored. A design of experiment study was conducted to understand the complete set of process parameters of a custom developed FDM 3D printer and their influence on tablet disintegration time. Nine settings in the Simplify 3D printing process design software were evaluated with further experimental investigation conducted on the influence of infill percentage, infill pattern, nozzle diameter, and layer height. The percentage of infill was identified as the most impactful parameter, as increasing it parabolically affected the increase of disintegration time. Furthermore, a larger nozzle diameter prolonged tablet disintegration, since thicker extruded strands are generated through wider nozzles during the printing process. Three infill patterns were selected for in-depth analysis, demonstrating the clear importance of the geometry of the internal structure to resist mechanical stress during the disintegration test. Lastly, layer height did not influence the disintegration time. A statistical model with accurate fit (R2 = 0.928) and predictability (Q2 = 0.847) was created. In addition, only the infill pattern and layer height influenced both the uniformity of mass and uniformity of the disintegration time, which demonstrates the robustness of the printing process.https://doi.org/10.2478/acph-2023-00263d printed tabletsdisintegration timefused deposition modellingdesign of experimentsprinting parametersuniformity of mass |
| spellingShingle | Kreft Klemen Stanić Tijana Perhavec Petra Dreu Rok Lavrič Zoran Influence of fused deposition modelling printing parameters on tablet disintegration times: a design of experiments study Acta Pharmaceutica 3d printed tablets disintegration time fused deposition modelling design of experiments printing parameters uniformity of mass |
| title | Influence of fused deposition modelling printing parameters on tablet disintegration times: a design of experiments study |
| title_full | Influence of fused deposition modelling printing parameters on tablet disintegration times: a design of experiments study |
| title_fullStr | Influence of fused deposition modelling printing parameters on tablet disintegration times: a design of experiments study |
| title_full_unstemmed | Influence of fused deposition modelling printing parameters on tablet disintegration times: a design of experiments study |
| title_short | Influence of fused deposition modelling printing parameters on tablet disintegration times: a design of experiments study |
| title_sort | influence of fused deposition modelling printing parameters on tablet disintegration times a design of experiments study |
| topic | 3d printed tablets disintegration time fused deposition modelling design of experiments printing parameters uniformity of mass |
| url | https://doi.org/10.2478/acph-2023-0026 |
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