MINERAL DENSITY AND METABOLISM OF BONE TISSUE IN PATIENTS WITH CHRONIC HEART FAILURE INSUFFICIENCY OF SENIOR AGE
The modern concepts about possible relationship between congestive heart failure and osteoporosis are described in the article. The results of bone mineral density and bone metabolism evaluation in very elderly patients with congestive heart failure (CHF) are presented. Bone mineral density was sign...
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SINAPS LLC
2017-05-01
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| Series: | Архивъ внутренней медицины |
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| Online Access: | https://www.medarhive.ru/jour/article/view/655 |
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| author | S. V. Topolyanskaya I. O. Osipovskaya L. S. Lifanova T. A. Eliseeva O. N. Vakulenko |
| author_facet | S. V. Topolyanskaya I. O. Osipovskaya L. S. Lifanova T. A. Eliseeva O. N. Vakulenko |
| author_sort | S. V. Topolyanskaya |
| collection | DOAJ |
| description | The modern concepts about possible relationship between congestive heart failure and osteoporosis are described in the article. The results of bone mineral density and bone metabolism evaluation in very elderly patients with congestive heart failure (CHF) are presented. Bone mineral density was significantly lower in CHF-patients compared to control group (age-matched patients with similar main diseases — coronary artery disease and arterial hypertension). Largest differences were observed in proximal femur (р=0.01). Greater differences in BMD were detected in female patients (p=0.002). The reduced osteoblast function was observed in CHF-patients; mean osteocalcin level was 1.23 ng/ml in the CHF-group and 4.16 ng/ml — in the control group (p=0.03). Also increase of Beta-Cross laps (bone resorption marker) was registered in CHF-patients (p=0.003 vs control group). The significant negative correlation between tumor necrosis factor-a concentration and bone mineral density (especially in proximal femur) was detected (p=0.03). TNF-a levels were higher in CHF-patients than in the control group (p=0.04). In addition, bone mineral density values were lower in patients with low leptin level than in those with normal and high leptin concentrations (p=0.006). Noteworthy that low leptin values were detected in CHF-patients only. |
| format | Article |
| id | doaj-art-57f83c1b7c4b4aab93ad2b05120e2ce2 |
| institution | Kabale University |
| issn | 2226-6704 2411-6564 |
| language | Russian |
| publishDate | 2017-05-01 |
| publisher | SINAPS LLC |
| record_format | Article |
| series | Архивъ внутренней медицины |
| spelling | doaj-art-57f83c1b7c4b4aab93ad2b05120e2ce22025-08-20T03:37:57ZrusSINAPS LLCАрхивъ внутренней медицины2226-67042411-65642017-05-017320521110.20514/2226-6704-2017-7-3-205-211598MINERAL DENSITY AND METABOLISM OF BONE TISSUE IN PATIENTS WITH CHRONIC HEART FAILURE INSUFFICIENCY OF SENIOR AGES. V. Topolyanskaya0I. O. Osipovskaya1L. S. Lifanova2T. A. Eliseeva3O. N. Vakulenko4I.M. Sechenov First Moscow State Medical UniversityHospital Veterans of Wars № 3 Department of Moscow Health, MoscowI.M. Sechenov First Moscow State Medical UniversityHospital Veterans of Wars № 3 Department of Moscow Health, MoscowHospital Veterans of Wars № 3 Department of Moscow Health, MoscowThe modern concepts about possible relationship between congestive heart failure and osteoporosis are described in the article. The results of bone mineral density and bone metabolism evaluation in very elderly patients with congestive heart failure (CHF) are presented. Bone mineral density was significantly lower in CHF-patients compared to control group (age-matched patients with similar main diseases — coronary artery disease and arterial hypertension). Largest differences were observed in proximal femur (р=0.01). Greater differences in BMD were detected in female patients (p=0.002). The reduced osteoblast function was observed in CHF-patients; mean osteocalcin level was 1.23 ng/ml in the CHF-group and 4.16 ng/ml — in the control group (p=0.03). Also increase of Beta-Cross laps (bone resorption marker) was registered in CHF-patients (p=0.003 vs control group). The significant negative correlation between tumor necrosis factor-a concentration and bone mineral density (especially in proximal femur) was detected (p=0.03). TNF-a levels were higher in CHF-patients than in the control group (p=0.04). In addition, bone mineral density values were lower in patients with low leptin level than in those with normal and high leptin concentrations (p=0.006). Noteworthy that low leptin values were detected in CHF-patients only.https://www.medarhive.ru/jour/article/view/655congestive heart failureosteoporosisfracturesbone mineral densityosteocalcinβ-cross lapsvery elderly |
| spellingShingle | S. V. Topolyanskaya I. O. Osipovskaya L. S. Lifanova T. A. Eliseeva O. N. Vakulenko MINERAL DENSITY AND METABOLISM OF BONE TISSUE IN PATIENTS WITH CHRONIC HEART FAILURE INSUFFICIENCY OF SENIOR AGE Архивъ внутренней медицины congestive heart failure osteoporosis fractures bone mineral density osteocalcin β-cross laps very elderly |
| title | MINERAL DENSITY AND METABOLISM OF BONE TISSUE IN PATIENTS WITH CHRONIC HEART FAILURE INSUFFICIENCY OF SENIOR AGE |
| title_full | MINERAL DENSITY AND METABOLISM OF BONE TISSUE IN PATIENTS WITH CHRONIC HEART FAILURE INSUFFICIENCY OF SENIOR AGE |
| title_fullStr | MINERAL DENSITY AND METABOLISM OF BONE TISSUE IN PATIENTS WITH CHRONIC HEART FAILURE INSUFFICIENCY OF SENIOR AGE |
| title_full_unstemmed | MINERAL DENSITY AND METABOLISM OF BONE TISSUE IN PATIENTS WITH CHRONIC HEART FAILURE INSUFFICIENCY OF SENIOR AGE |
| title_short | MINERAL DENSITY AND METABOLISM OF BONE TISSUE IN PATIENTS WITH CHRONIC HEART FAILURE INSUFFICIENCY OF SENIOR AGE |
| title_sort | mineral density and metabolism of bone tissue in patients with chronic heart failure insufficiency of senior age |
| topic | congestive heart failure osteoporosis fractures bone mineral density osteocalcin β-cross laps very elderly |
| url | https://www.medarhive.ru/jour/article/view/655 |
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