The Influence of COVID-19 on Antimicrobial Resistance Trends at a Secondary Care Hospital in Slovenia: An Interrupted Time Series Analysis
<b>Background/Objectives.</b> Our study aimed to determine the development of antibiotic resistance during the peri-pandemic period in a regional secondary care hospital using an interrupted time series analysis. <b>Methods</b>. We analyzed data from seven years, accounting f...
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MDPI AG
2024-11-01
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| Online Access: | https://www.mdpi.com/2079-6382/13/11/1033 |
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| author | Samo Jeverica Darja Barlič Maganja Jani Dernič Peter Golob Alenka Stepišnik Bojan Novak Lea Papst Anamarija Juriševič Dodič Mladen Gasparini |
| author_facet | Samo Jeverica Darja Barlič Maganja Jani Dernič Peter Golob Alenka Stepišnik Bojan Novak Lea Papst Anamarija Juriševič Dodič Mladen Gasparini |
| author_sort | Samo Jeverica |
| collection | DOAJ |
| description | <b>Background/Objectives.</b> Our study aimed to determine the development of antibiotic resistance during the peri-pandemic period in a regional secondary care hospital using an interrupted time series analysis. <b>Methods</b>. We analyzed data from seven years, accounting for 441,149 patient days. The incidence density of multidrug-resistant bacteria (MDR) burden and infection was reported per 1000 patient days. <b>Results.</b> During the COVID-19 period, a significant increase in the mean incidence density of the total MDR burden from 4.93 to 5.81 per 1000 patient days was observed (<i>p</i> = 0.007). On the other hand, the mean incidence density of MDR infections decreased from 1.61 to 1.29 per 1000 patient days (<i>p</i> = 0.019). Using the interrupted time series analysis, the same trends were observed, namely the overall increasing trend in MDR burden and the overall decreasing trend in MDR infections. This divergent trend is mainly due to similar trends in several Gram-negative MDR, namely ESBL-EC, ESBL-KP and CRE. <b>Conclusions.</b> Due to the increasing burden of MDR, it is necessary to strengthen AMR surveillance. In addition, strict infection prevention and control measures, and antimicrobial stewardship programs continue to be important components in the fight against resistant bacteria. |
| format | Article |
| id | doaj-art-57f7cb0c6d264b2d9380a3f8413f6674 |
| institution | OA Journals |
| issn | 2079-6382 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| series | Antibiotics |
| spelling | doaj-art-57f7cb0c6d264b2d9380a3f8413f66742025-08-20T02:08:00ZengMDPI AGAntibiotics2079-63822024-11-011311103310.3390/antibiotics13111033The Influence of COVID-19 on Antimicrobial Resistance Trends at a Secondary Care Hospital in Slovenia: An Interrupted Time Series AnalysisSamo Jeverica0Darja Barlič Maganja1Jani Dernič2Peter Golob3Alenka Stepišnik4Bojan Novak5Lea Papst6Anamarija Juriševič Dodič7Mladen Gasparini8Izola General Hospital, 6310 Izola, SloveniaFaculty of Health Sciences, University of Primorska, 6000 Koper, SloveniaIzola General Hospital, 6310 Izola, SloveniaIzola General Hospital, 6310 Izola, SloveniaIzola General Hospital, 6310 Izola, SloveniaIzola General Hospital, 6310 Izola, SloveniaDepartment of Infectious Diseases, University Medical Centre Ljubljana, 1000 Ljubljana, SloveniaDepartment of Medical Microbiology Koper, National Laboratory of Health, Environment and Food, 2000 Maribor, SloveniaIzola General Hospital, 6310 Izola, Slovenia<b>Background/Objectives.</b> Our study aimed to determine the development of antibiotic resistance during the peri-pandemic period in a regional secondary care hospital using an interrupted time series analysis. <b>Methods</b>. We analyzed data from seven years, accounting for 441,149 patient days. The incidence density of multidrug-resistant bacteria (MDR) burden and infection was reported per 1000 patient days. <b>Results.</b> During the COVID-19 period, a significant increase in the mean incidence density of the total MDR burden from 4.93 to 5.81 per 1000 patient days was observed (<i>p</i> = 0.007). On the other hand, the mean incidence density of MDR infections decreased from 1.61 to 1.29 per 1000 patient days (<i>p</i> = 0.019). Using the interrupted time series analysis, the same trends were observed, namely the overall increasing trend in MDR burden and the overall decreasing trend in MDR infections. This divergent trend is mainly due to similar trends in several Gram-negative MDR, namely ESBL-EC, ESBL-KP and CRE. <b>Conclusions.</b> Due to the increasing burden of MDR, it is necessary to strengthen AMR surveillance. In addition, strict infection prevention and control measures, and antimicrobial stewardship programs continue to be important components in the fight against resistant bacteria.https://www.mdpi.com/2079-6382/13/11/1033antimicrobial resistanceCOVID-19Sloveniainterrupted time series analysis |
| spellingShingle | Samo Jeverica Darja Barlič Maganja Jani Dernič Peter Golob Alenka Stepišnik Bojan Novak Lea Papst Anamarija Juriševič Dodič Mladen Gasparini The Influence of COVID-19 on Antimicrobial Resistance Trends at a Secondary Care Hospital in Slovenia: An Interrupted Time Series Analysis Antibiotics antimicrobial resistance COVID-19 Slovenia interrupted time series analysis |
| title | The Influence of COVID-19 on Antimicrobial Resistance Trends at a Secondary Care Hospital in Slovenia: An Interrupted Time Series Analysis |
| title_full | The Influence of COVID-19 on Antimicrobial Resistance Trends at a Secondary Care Hospital in Slovenia: An Interrupted Time Series Analysis |
| title_fullStr | The Influence of COVID-19 on Antimicrobial Resistance Trends at a Secondary Care Hospital in Slovenia: An Interrupted Time Series Analysis |
| title_full_unstemmed | The Influence of COVID-19 on Antimicrobial Resistance Trends at a Secondary Care Hospital in Slovenia: An Interrupted Time Series Analysis |
| title_short | The Influence of COVID-19 on Antimicrobial Resistance Trends at a Secondary Care Hospital in Slovenia: An Interrupted Time Series Analysis |
| title_sort | influence of covid 19 on antimicrobial resistance trends at a secondary care hospital in slovenia an interrupted time series analysis |
| topic | antimicrobial resistance COVID-19 Slovenia interrupted time series analysis |
| url | https://www.mdpi.com/2079-6382/13/11/1033 |
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