Relationship between personal anxiety and genes associated with eating disorders in women aged 45-64
Aim. To study the possible relationship between personal anxiety and polymorphic variants of genes associated with eating disorders (rs17782313 MC4R, rs1800497 DRD2, rs9939609 FTO) in women aged 45-64 in Novosibirsk.Material and methods. A random representative sample of women aged 45-64 years (n=10...
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«SILICEA-POLIGRAF» LLC
2024-10-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/4043 |
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| author | V. V. Gafarov E. A. Gromova I. V. Gagulin V. N. Maksimov A. V. Gafarova |
| author_facet | V. V. Gafarov E. A. Gromova I. V. Gagulin V. N. Maksimov A. V. Gafarova |
| author_sort | V. V. Gafarov |
| collection | DOAJ |
| description | Aim. To study the possible relationship between personal anxiety and polymorphic variants of genes associated with eating disorders (rs17782313 MC4R, rs1800497 DRD2, rs9939609 FTO) in women aged 45-64 in Novosibirsk.Material and methods. A random representative sample of women aged 45-64 years (n=1074, mean age, 54,27±0,2 years) was examined in 2003-2005 at the Research Institute of Internal and Preventive Medicine, a branch of the Institute of Cytology and Genetics, within the Health, Alcohol and Psychosocial Factors In Eastern Europe (HAPIEE) project. Personal anxiety was assessed using the Spielberger self-assessment questionnaire included in the protocol of the Multinational Monitoring of Trends and Determinants of Cardiovascular Disease — Optional Psychosocial Study (MONICA-MOPSY), tested at screenings of the World Health Organization (WHO) MONICA program in 1983-1995. The sample for the HAPIEE program was formed at the program data processing center in Prague for each of the collaborating centers in such a way that each respondent was random. From the sample, every second woman (n=537) was selected for genotyping of the FTO rs9939609 variant (n=384); every third woman (n=358) — for genotyping the MC4R rs17782313 (n=279) and DRD2 rs1800497 variants (n=327). Genotyping was performed in the laboratory of molecular genetic studies by the polymerase chain reaction with the analysis of restriction fragment length polymorphism.Results. Among women aged 45-64, anxiety was detected in 58,3%, and in 15,9% of women the anxiety level was high. The homozygous genotype C/C rs17782313 of the MC4R gene was more common among women with high anxiety levels (17,5%) than among women with low and moderate anxiety levels (1,8 and 0,8%, respectively; p=0,001). There were no significant differences in the detection rate of the rs1800497 genotypes of the DRD2 gene among women with different levels of anxiety (p>0,05). The frequency of the A/A rs9939609 genotype of the FTO gene was highest among women with high anxiety levels — 29,5%, compared to participants with low and moderate anxiety levels (15 and 15,3%, respectively; p=0,048). The probability of anxiety among carriers of the C/C+C/T genotypes of the MC4R gene was 1,29 times higher than among carriers of the T/T genotype (p=0,001). Among carriers of the A/A rs9939609 genotype of the FTO gene, the anxiety probability was 2,34 times higher than among carriers of the A/T+T/T genotypes (p=0,008).Conclusion. The association between anxiety and genes of eating disorders dictates the need for diagnosis and subsequent treatment of anxiety and its associated consequences. |
| format | Article |
| id | doaj-art-57f644264868419086f3b5c41e32c07d |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2024-10-01 |
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| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-57f644264868419086f3b5c41e32c07d2025-08-20T03:35:51Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252024-10-0123910.15829/1728-8800-2024-40433076Relationship between personal anxiety and genes associated with eating disorders in women aged 45-64V. V. Gafarov0E. A. Gromova1I. V. Gagulin2V. N. Maksimov3A. V. Gafarova4Research Institute of Internal and Preventive Medicine — branch of the Research Institute of Cytology and GeneticsResearch Institute of Internal and Preventive Medicine — branch of the Research Institute of Cytology and GeneticsResearch Institute of Internal and Preventive Medicine — branch of the Research Institute of Cytology and GeneticsResearch Institute of Internal and Preventive Medicine — branch of the Research Institute of Cytology and GeneticsResearch Institute of Internal and Preventive Medicine — branch of the Research Institute of Cytology and GeneticsAim. To study the possible relationship between personal anxiety and polymorphic variants of genes associated with eating disorders (rs17782313 MC4R, rs1800497 DRD2, rs9939609 FTO) in women aged 45-64 in Novosibirsk.Material and methods. A random representative sample of women aged 45-64 years (n=1074, mean age, 54,27±0,2 years) was examined in 2003-2005 at the Research Institute of Internal and Preventive Medicine, a branch of the Institute of Cytology and Genetics, within the Health, Alcohol and Psychosocial Factors In Eastern Europe (HAPIEE) project. Personal anxiety was assessed using the Spielberger self-assessment questionnaire included in the protocol of the Multinational Monitoring of Trends and Determinants of Cardiovascular Disease — Optional Psychosocial Study (MONICA-MOPSY), tested at screenings of the World Health Organization (WHO) MONICA program in 1983-1995. The sample for the HAPIEE program was formed at the program data processing center in Prague for each of the collaborating centers in such a way that each respondent was random. From the sample, every second woman (n=537) was selected for genotyping of the FTO rs9939609 variant (n=384); every third woman (n=358) — for genotyping the MC4R rs17782313 (n=279) and DRD2 rs1800497 variants (n=327). Genotyping was performed in the laboratory of molecular genetic studies by the polymerase chain reaction with the analysis of restriction fragment length polymorphism.Results. Among women aged 45-64, anxiety was detected in 58,3%, and in 15,9% of women the anxiety level was high. The homozygous genotype C/C rs17782313 of the MC4R gene was more common among women with high anxiety levels (17,5%) than among women with low and moderate anxiety levels (1,8 and 0,8%, respectively; p=0,001). There were no significant differences in the detection rate of the rs1800497 genotypes of the DRD2 gene among women with different levels of anxiety (p>0,05). The frequency of the A/A rs9939609 genotype of the FTO gene was highest among women with high anxiety levels — 29,5%, compared to participants with low and moderate anxiety levels (15 and 15,3%, respectively; p=0,048). The probability of anxiety among carriers of the C/C+C/T genotypes of the MC4R gene was 1,29 times higher than among carriers of the T/T genotype (p=0,001). Among carriers of the A/A rs9939609 genotype of the FTO gene, the anxiety probability was 2,34 times higher than among carriers of the A/T+T/T genotypes (p=0,008).Conclusion. The association between anxiety and genes of eating disorders dictates the need for diagnosis and subsequent treatment of anxiety and its associated consequences.https://cardiovascular.elpub.ru/jour/article/view/4043anxietyeating disordermc4r rs17782313 variantdrd2 rs1800497 variantfto rs9939609 variant |
| spellingShingle | V. V. Gafarov E. A. Gromova I. V. Gagulin V. N. Maksimov A. V. Gafarova Relationship between personal anxiety and genes associated with eating disorders in women aged 45-64 Кардиоваскулярная терапия и профилактика anxiety eating disorder mc4r rs17782313 variant drd2 rs1800497 variant fto rs9939609 variant |
| title | Relationship between personal anxiety and genes associated with eating disorders in women aged 45-64 |
| title_full | Relationship between personal anxiety and genes associated with eating disorders in women aged 45-64 |
| title_fullStr | Relationship between personal anxiety and genes associated with eating disorders in women aged 45-64 |
| title_full_unstemmed | Relationship between personal anxiety and genes associated with eating disorders in women aged 45-64 |
| title_short | Relationship between personal anxiety and genes associated with eating disorders in women aged 45-64 |
| title_sort | relationship between personal anxiety and genes associated with eating disorders in women aged 45 64 |
| topic | anxiety eating disorder mc4r rs17782313 variant drd2 rs1800497 variant fto rs9939609 variant |
| url | https://cardiovascular.elpub.ru/jour/article/view/4043 |
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