Receptor Proteins in Selective Autophagy
Autophagy has long been thought to be an essential but unselective bulk degradation pathway. However, increasing evidence suggests selective autophagosomal turnover of a broad range of substrates. Bifunctional autophagy receptors play a key role in selective autophagy by tethering cargo to the site...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/673290 |
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| _version_ | 1832559899265990656 |
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| author | Christian Behrends Simone Fulda |
| author_facet | Christian Behrends Simone Fulda |
| author_sort | Christian Behrends |
| collection | DOAJ |
| description | Autophagy has long been thought to be an essential but unselective bulk degradation pathway. However, increasing evidence suggests selective autophagosomal turnover of a broad range of substrates. Bifunctional autophagy receptors play a key role in selective autophagy by tethering cargo to the site of autophagosomal engulfment. While the identity of molecular components involved in selective autophagy has been revealed at least to some extent, we are only beginning to understand how selectivity is achieved in this process. Here, we summarize the mechanistic and structural basis of receptor-mediated selective autophagy. |
| format | Article |
| id | doaj-art-57f5f8a4eeec44d7bcee5f5033fc3bc9 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-57f5f8a4eeec44d7bcee5f5033fc3bc92025-02-03T01:28:59ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/673290673290Receptor Proteins in Selective AutophagyChristian Behrends0Simone Fulda1Institute of Biochemistry II, Goethe University School of Medicine, 60590 Frankfurt, GermanyInstitute for Experimental Cancer Research in Pediatrics, Goethe University, 60590 Frankfurt, GermanyAutophagy has long been thought to be an essential but unselective bulk degradation pathway. However, increasing evidence suggests selective autophagosomal turnover of a broad range of substrates. Bifunctional autophagy receptors play a key role in selective autophagy by tethering cargo to the site of autophagosomal engulfment. While the identity of molecular components involved in selective autophagy has been revealed at least to some extent, we are only beginning to understand how selectivity is achieved in this process. Here, we summarize the mechanistic and structural basis of receptor-mediated selective autophagy.http://dx.doi.org/10.1155/2012/673290 |
| spellingShingle | Christian Behrends Simone Fulda Receptor Proteins in Selective Autophagy International Journal of Cell Biology |
| title | Receptor Proteins in Selective Autophagy |
| title_full | Receptor Proteins in Selective Autophagy |
| title_fullStr | Receptor Proteins in Selective Autophagy |
| title_full_unstemmed | Receptor Proteins in Selective Autophagy |
| title_short | Receptor Proteins in Selective Autophagy |
| title_sort | receptor proteins in selective autophagy |
| url | http://dx.doi.org/10.1155/2012/673290 |
| work_keys_str_mv | AT christianbehrends receptorproteinsinselectiveautophagy AT simonefulda receptorproteinsinselectiveautophagy |