Hypervirulent Klebsiella pneumoniae: Epidemiology, virulence factors, and antibiotic resistance
Human infections induced by Klebsiella pneumoniae (K. pneumoniae) include pneumonia; urinary tract infections, liver abscesses, bacteremia, and others. The introduction and spread of the hypervirulent K. pneumoniae (hvKp) strains have raised the number of persons who are already susceptible to infec...
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| Format: | Article |
| Language: | English |
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ResearchersLinks, Ltd
2023-02-01
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| Series: | Novel Research in Microbiology Journal |
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| Online Access: | https://nrmj.journals.ekb.eg/article_287177_7363f452e7654e9a2cf3e98e20787129.pdf |
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| author | Enas M. Hefzy Reda M. Taha Safaa Abd El Salam Abdelrhman Abdelmoktader Mahmoud A.F. Khalil |
| author_facet | Enas M. Hefzy Reda M. Taha Safaa Abd El Salam Abdelrhman Abdelmoktader Mahmoud A.F. Khalil |
| author_sort | Enas M. Hefzy |
| collection | DOAJ |
| description | Human infections induced by Klebsiella pneumoniae (K. pneumoniae) include pneumonia; urinary tract infections, liver abscesses, bacteremia, and others. The introduction and spread of the hypervirulent K. pneumoniae (hvKp) strains have raised the number of persons who are already susceptible to infections, including those who are healthy or immune-compromised. Infections can occur worldwide; however, they are particularly prevalent in the Asia-Pacific area. Virulence plasmids as well as other conjugal components contain the genetic material that gives hvKp its hypervirulence phenotype. Although the vast majority of hvKp isolates are antibiotic-susceptible, the incidence of virulent as well as resistant isolates, such as carbapenem-resistant hvKp isolates, is continuously growing. Multidrug resistance (MDR) and increased virulence of these strains may be the cause of the subsequent clinical crisis. This study aimed to review and analyse the epidemiology, the factors associated with hypervirulence, and the mechanisms of antibiotic resistance of the hvKp strains in order to provide a better understanding of the basic biology of these strains. |
| format | Article |
| id | doaj-art-57f098b45e744ef6891e309c3be3822b |
| institution | DOAJ |
| issn | 2537-0286 2537-0294 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | ResearchersLinks, Ltd |
| record_format | Article |
| series | Novel Research in Microbiology Journal |
| spelling | doaj-art-57f098b45e744ef6891e309c3be3822b2025-08-20T03:19:34ZengResearchersLinks, LtdNovel Research in Microbiology Journal2537-02862537-02942023-02-01711857187210.21608/nrmj.2023.287177Hypervirulent Klebsiella pneumoniae: Epidemiology, virulence factors, and antibiotic resistanceEnas M. Hefzy0Reda M. Taha1Safaa Abd El Salam2Abdelrhman Abdelmoktader3Mahmoud A.F. Khalil4Medical Microbiology and Immunology Department, Faculty of Medicine, Fayoum University, Fayoum, EgyptBotany Department, Faculty of Science, Fayoum University, Fayoum, EgyptBotany Department, Faculty of Science, Fayoum University, Fayoum, EgyptMedical Microbiology and Immunology Department, Faculty of Medicine, Fayoum University, Fayoum, EgyptMicrobiology Department, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt Human infections induced by Klebsiella pneumoniae (K. pneumoniae) include pneumonia; urinary tract infections, liver abscesses, bacteremia, and others. The introduction and spread of the hypervirulent K. pneumoniae (hvKp) strains have raised the number of persons who are already susceptible to infections, including those who are healthy or immune-compromised. Infections can occur worldwide; however, they are particularly prevalent in the Asia-Pacific area. Virulence plasmids as well as other conjugal components contain the genetic material that gives hvKp its hypervirulence phenotype. Although the vast majority of hvKp isolates are antibiotic-susceptible, the incidence of virulent as well as resistant isolates, such as carbapenem-resistant hvKp isolates, is continuously growing. Multidrug resistance (MDR) and increased virulence of these strains may be the cause of the subsequent clinical crisis. This study aimed to review and analyse the epidemiology, the factors associated with hypervirulence, and the mechanisms of antibiotic resistance of the hvKp strains in order to provide a better understanding of the basic biology of these strains. https://nrmj.journals.ekb.eg/article_287177_7363f452e7654e9a2cf3e98e20787129.pdfhypervirulent klebsiella pneumoniaehypermucoviscosityaerobactinvirulence plasmids |
| spellingShingle | Enas M. Hefzy Reda M. Taha Safaa Abd El Salam Abdelrhman Abdelmoktader Mahmoud A.F. Khalil Hypervirulent Klebsiella pneumoniae: Epidemiology, virulence factors, and antibiotic resistance Novel Research in Microbiology Journal hypervirulent klebsiella pneumoniae hypermucoviscosity aerobactin virulence plasmids |
| title | Hypervirulent Klebsiella pneumoniae: Epidemiology, virulence factors, and antibiotic resistance |
| title_full | Hypervirulent Klebsiella pneumoniae: Epidemiology, virulence factors, and antibiotic resistance |
| title_fullStr | Hypervirulent Klebsiella pneumoniae: Epidemiology, virulence factors, and antibiotic resistance |
| title_full_unstemmed | Hypervirulent Klebsiella pneumoniae: Epidemiology, virulence factors, and antibiotic resistance |
| title_short | Hypervirulent Klebsiella pneumoniae: Epidemiology, virulence factors, and antibiotic resistance |
| title_sort | hypervirulent klebsiella pneumoniae epidemiology virulence factors and antibiotic resistance |
| topic | hypervirulent klebsiella pneumoniae hypermucoviscosity aerobactin virulence plasmids |
| url | https://nrmj.journals.ekb.eg/article_287177_7363f452e7654e9a2cf3e98e20787129.pdf |
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