The N-6 methyladenosine dynamics in STEMI and the effect of IL-6 inhibition - a hypothesis generating sub-study of the ASSAIL-MI trial

The N-6 methyladenosine dynamics in STEMI and the effect of IL-6 inhibition - a hypothesis generating sub-study of the ASSAIL-MI trial

BackgroundEpitranscriptomics, with m6A as the most prevalent in mammals, is a novel treatment target for inflammatory diseases, including cardiovascular diseases. However, little is known about m6A RNA-regulation during myocardial infarction (MI).MethodsIn this explorative sub-study of the ASSAIL-MI...

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Main Authors: Tuva B. Dahl, Ana Quiles-Jiménez, Kaspar Broch, Anne Kristine Anstensrud, Lars Gullestad, Geir Ø. Andersen, Ola Kleveland, Jonas Øgaard, Vigdis Bjerkeli, Azita Rashidi, Kuan Yang, Kirsten B. Holven, Pål Aukrust, Magnar Bjørås, Camilla Huse, Bente Halvorsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
N6-methyladenosine (m6A)
epitranscriptome
RNA methylation
STEMI
inflammation
tocilizumab
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1532325/full
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