Modeling Epithelial Homeostasis and Perturbation in Three-Dimensional Human Esophageal Organoids

Modeling Epithelial Homeostasis and Perturbation in Three-Dimensional Human Esophageal Organoids

<b>Background:</b> Esophageal organoids from a variety of pathologies including cancer are grown in Advanced Dulbecco’s Modified Eagle Medium-Nutrient Mixture F12 (hereafter ADF). However, the currently available ADF-based formulations are suboptimal for normal human esophageal organoids...

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Main Authors: Masataka Shimonosono, Masaki Morimoto, Wataru Hirose, Yasuto Tomita, Norihiro Matsuura, Samuel Flashner, Mesra S. Ebadi, Emilea H. Okayasu, Christian Y. Lee, William R. Britton, Cecilia Martin, Beverly R. Wuertz, Anuraag S. Parikh, Uma M. Sachdeva, Frank G. Ondrey, Venkatram R. Atigadda, Craig A. Elmets, Julian A. Abrams, Amanda B. Muir, Andres J. Klein-Szanto, Kenneth I. Weinberg, Fatemeh Momen-Heravi, Hiroshi Nakagawa
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Biomolecules
Subjects:
esophagus
organoids
epidermal growth factor
transforming growth factor-β
basal cell hyperplasia
eosinophilic esophagitis
Online Access:https://www.mdpi.com/2218-273X/14/9/1126
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