The results of the detection of specific IgG antibodies to Ebola virus (Filoviridae: <i>Orthoebolavirus</i>) in residents of the Republic of Guinea after the end of the epidemic
Introduction. In 2014–2016, an epidemic of Ebola virus disease (EVD) was registered in Guinea. In 2021, EVD cases were repeated in the region. The importance of studying the duration of post-infection immunity to the Ebola virus in the body of convalescents is due to the fact that after the end of t...
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Central Research Institute for Epidemiology
2025-04-01
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| Series: | Вопросы вирусологии |
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| Online Access: | https://virusjour.crie.ru/jour/article/viewFile/16710/969 |
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| author | Ekaterina V. Naidenova Mikhail Yu. Kartashov Irina S. Shulgina Stepan A. Pyankov Maxim A. Kulagin Mamadou B. Bah Ibrahim Nourdine Magassouba N’Fally Viktor Konomou Mohamed S. Traore Sanaba Boumbaly Vladimir V. Kutyrev |
| author_facet | Ekaterina V. Naidenova Mikhail Yu. Kartashov Irina S. Shulgina Stepan A. Pyankov Maxim A. Kulagin Mamadou B. Bah Ibrahim Nourdine Magassouba N’Fally Viktor Konomou Mohamed S. Traore Sanaba Boumbaly Vladimir V. Kutyrev |
| author_sort | Ekaterina V. Naidenova |
| collection | DOAJ |
| description | Introduction. In 2014–2016, an epidemic of Ebola virus disease (EVD) was registered in Guinea. In 2021, EVD cases were repeated in the region. The importance of studying the duration of post-infection immunity to the Ebola virus in the body of convalescents is due to the fact that after the end of the epidemic they can be the main sources of infection. One of the indicators of the pathogen circulation in a certain area is the detection of specific IgG antibodies in the blood sera of the inhabitants.
The aim of the study is to identify IgG immunoglobulins to Ebola virus in the blood sera of reconvalescents and practically healthy residents of the Republic of Guinea after the end of the epidemic.
Materials and methods. The ELISA method was used to test the blood sera of 9 patients treated at the NKDCEM hospital (Kindia), collected after the end of the disease and up to 72 months after recovery, and 3939 blood serum samples from practically healthy residents of Guinea.
Results. IgG antibodies in the blood sera of reconvalescents a month after recovery were detected in a titer of up to 1 : 800. By 12 months, the antibody level decreased to 1 : 100 and remained at this level for up to 48 months. After 6 years of observation, no antibodies were registered. Among the 3939 blood samples from healthy residents, IgG immunoglobulins to the Ebola virus were detected in 5.6%. Most of the positive samples were collected in Forest Guinea (7.7%), and a smaller part in Upper Guinea (4.5%). The maximum percentage of positive samples was detected in people over 70 years of age (12.3%).
Conclusion. In our case, it was shown that a high level of post-infection immunity in the blood sera of patients with EVD persists for the first 6 months, this corresponds to the data obtained by other authors, and does not exclude the possibility of re-infection. The highest level of the seroprevalence is registered in Forest Guinea. This indicates the active circulation of the pathogen and the constant contact of the inhabitants of the region with it, which leads to epidemiological complications. |
| format | Article |
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| issn | 0507-4088 2411-2097 |
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| publishDate | 2025-04-01 |
| publisher | Central Research Institute for Epidemiology |
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| series | Вопросы вирусологии |
| spelling | doaj-art-57e9c06ddcc44586b557f21e6fca091a2025-08-20T02:38:41ZengCentral Research Institute for EpidemiologyВопросы вирусологии0507-40882411-20972025-04-0170215416310.36233/0507-4088-2881271The results of the detection of specific IgG antibodies to Ebola virus (Filoviridae: <i>Orthoebolavirus</i>) in residents of the Republic of Guinea after the end of the epidemicEkaterina V. Naidenova0https://orcid.org/0000-0001-6474-3696Mikhail Yu. Kartashov1https://orcid.org/0000-0002-7857-6822Irina S. Shulgina2https://orcid.org/0000-0002-6850-338XStepan A. Pyankov3https://orcid.org/0000-0002-6593-6614Maxim A. Kulagin4https://orcid.org/0000-0002-6423-1460Mamadou B. Bah5https://orcid.org/0000-0002-4565-269XIbrahim Nourdine6https://orcid.org/0000-0002-2970-9676Magassouba N’Fally7https://orcid.org/0000-0002-3760-6642Viktor Konomou8https://orcid.org/0009-0007-5010-0041Mohamed S. Traore9https://orcid.org/0000-0002-3811-8675Sanaba Boumbaly10https://orcid.org/0000-0002-4506-6033Vladimir V. Kutyrev11https://orcid.org/0000-0003-3788-3452Russian Research Anti-Plague Institute «Microbe» of the Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor)State Scientific Center of Virology and Biotechnology «Vector» of the Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor)State Scientific Center of Virology and Biotechnology «Vector» of the Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor)State Scientific Center of Virology and Biotechnology «Vector» of the Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor)Russian Research Anti-Plague Institute «Microbe» of the Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor)Research Institute of Applied Biology of GuineaVirological Research Center, Laboratory of Viral Hemorrhagic Fevers of GuineaVirological Research Center, Laboratory of Viral Hemorrhagic Fevers of GuineaScientific Clinical and Diagnostic Center of Epidemiology and MicrobiologyResearch Institute of Applied Biology of GuineaVirological Research Center, Laboratory of Viral Hemorrhagic Fevers of GuineaRussian Research Anti-Plague Institute «Microbe» of the Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor)Introduction. In 2014–2016, an epidemic of Ebola virus disease (EVD) was registered in Guinea. In 2021, EVD cases were repeated in the region. The importance of studying the duration of post-infection immunity to the Ebola virus in the body of convalescents is due to the fact that after the end of the epidemic they can be the main sources of infection. One of the indicators of the pathogen circulation in a certain area is the detection of specific IgG antibodies in the blood sera of the inhabitants. The aim of the study is to identify IgG immunoglobulins to Ebola virus in the blood sera of reconvalescents and practically healthy residents of the Republic of Guinea after the end of the epidemic. Materials and methods. The ELISA method was used to test the blood sera of 9 patients treated at the NKDCEM hospital (Kindia), collected after the end of the disease and up to 72 months after recovery, and 3939 blood serum samples from practically healthy residents of Guinea. Results. IgG antibodies in the blood sera of reconvalescents a month after recovery were detected in a titer of up to 1 : 800. By 12 months, the antibody level decreased to 1 : 100 and remained at this level for up to 48 months. After 6 years of observation, no antibodies were registered. Among the 3939 blood samples from healthy residents, IgG immunoglobulins to the Ebola virus were detected in 5.6%. Most of the positive samples were collected in Forest Guinea (7.7%), and a smaller part in Upper Guinea (4.5%). The maximum percentage of positive samples was detected in people over 70 years of age (12.3%). Conclusion. In our case, it was shown that a high level of post-infection immunity in the blood sera of patients with EVD persists for the first 6 months, this corresponds to the data obtained by other authors, and does not exclude the possibility of re-infection. The highest level of the seroprevalence is registered in Forest Guinea. This indicates the active circulation of the pathogen and the constant contact of the inhabitants of the region with it, which leads to epidemiological complications.https://virusjour.crie.ru/jour/article/viewFile/16710/969igg class immunoglobulinsebola virus diseaseebola virusimmune layerrepublic of guineaelisa |
| spellingShingle | Ekaterina V. Naidenova Mikhail Yu. Kartashov Irina S. Shulgina Stepan A. Pyankov Maxim A. Kulagin Mamadou B. Bah Ibrahim Nourdine Magassouba N’Fally Viktor Konomou Mohamed S. Traore Sanaba Boumbaly Vladimir V. Kutyrev The results of the detection of specific IgG antibodies to Ebola virus (Filoviridae: <i>Orthoebolavirus</i>) in residents of the Republic of Guinea after the end of the epidemic Вопросы вирусологии igg class immunoglobulins ebola virus disease ebola virus immune layer republic of guinea elisa |
| title | The results of the detection of specific IgG antibodies to Ebola virus (Filoviridae: <i>Orthoebolavirus</i>) in residents of the Republic of Guinea after the end of the epidemic |
| title_full | The results of the detection of specific IgG antibodies to Ebola virus (Filoviridae: <i>Orthoebolavirus</i>) in residents of the Republic of Guinea after the end of the epidemic |
| title_fullStr | The results of the detection of specific IgG antibodies to Ebola virus (Filoviridae: <i>Orthoebolavirus</i>) in residents of the Republic of Guinea after the end of the epidemic |
| title_full_unstemmed | The results of the detection of specific IgG antibodies to Ebola virus (Filoviridae: <i>Orthoebolavirus</i>) in residents of the Republic of Guinea after the end of the epidemic |
| title_short | The results of the detection of specific IgG antibodies to Ebola virus (Filoviridae: <i>Orthoebolavirus</i>) in residents of the Republic of Guinea after the end of the epidemic |
| title_sort | results of the detection of specific igg antibodies to ebola virus filoviridae i orthoebolavirus i in residents of the republic of guinea after the end of the epidemic |
| topic | igg class immunoglobulins ebola virus disease ebola virus immune layer republic of guinea elisa |
| url | https://virusjour.crie.ru/jour/article/viewFile/16710/969 |
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