Gene-Drug Interaction in Stroke
Stroke is the third cause of mortality and one of most frequent causes of long-term neurological disability, as well as a complex disease that results from the interaction of environmental and genetic factors. The focus on genetics has produced a large number of studies with the objective of reveali...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.4061/2011/212485 |
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| _version_ | 1849415151575367680 |
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| author | Serena Amici Maurizio Paciaroni Giancarlo Agnelli Valeria Caso |
| author_facet | Serena Amici Maurizio Paciaroni Giancarlo Agnelli Valeria Caso |
| author_sort | Serena Amici |
| collection | DOAJ |
| description | Stroke is the third cause of mortality and one of most frequent causes of long-term neurological disability, as well as a complex disease that results from the interaction of environmental and genetic factors. The focus on genetics has produced a large number of studies with the objective of revealing the genetic basis of cerebrovascular diseases. Furthermore, pharmacogenetic research has investigated the relation between genetic variability and drug effectiveness/toxicity. This review will examine the implications of pharmacogenetics of stroke; data on antihypertensives, statins, antiplatelets, anticoagulants, and recombinant tissue plasminogen activator will be illustrated.
Several polymorphisms have been studied and some have been associated with positive drug-gene interaction on stroke, but the superiority of the genotype-guided approach over the clinical approach has not been proved yet; for this reason, it is not routinely recommended. |
| format | Article |
| id | doaj-art-57e74fb43e4f4e1c91f630d084f14a2b |
| institution | Kabale University |
| issn | 2042-0056 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke Research and Treatment |
| spelling | doaj-art-57e74fb43e4f4e1c91f630d084f14a2b2025-08-20T03:33:37ZengWileyStroke Research and Treatment2042-00562011-01-01201110.4061/2011/212485212485Gene-Drug Interaction in StrokeSerena Amici0Maurizio Paciaroni1Giancarlo Agnelli2Valeria Caso3Stroke Unit, Division of Cardiovascular Medicine, University of Perugia, Santa Maria della Misericordia Hospital, Sant'Andrea delle Fratte, 06126 Perugia, ItalyStroke Unit, Division of Cardiovascular Medicine, University of Perugia, Santa Maria della Misericordia Hospital, Sant'Andrea delle Fratte, 06126 Perugia, ItalyStroke Unit, Division of Cardiovascular Medicine, University of Perugia, Santa Maria della Misericordia Hospital, Sant'Andrea delle Fratte, 06126 Perugia, ItalyStroke Unit, Division of Cardiovascular Medicine, University of Perugia, Santa Maria della Misericordia Hospital, Sant'Andrea delle Fratte, 06126 Perugia, ItalyStroke is the third cause of mortality and one of most frequent causes of long-term neurological disability, as well as a complex disease that results from the interaction of environmental and genetic factors. The focus on genetics has produced a large number of studies with the objective of revealing the genetic basis of cerebrovascular diseases. Furthermore, pharmacogenetic research has investigated the relation between genetic variability and drug effectiveness/toxicity. This review will examine the implications of pharmacogenetics of stroke; data on antihypertensives, statins, antiplatelets, anticoagulants, and recombinant tissue plasminogen activator will be illustrated. Several polymorphisms have been studied and some have been associated with positive drug-gene interaction on stroke, but the superiority of the genotype-guided approach over the clinical approach has not been proved yet; for this reason, it is not routinely recommended.http://dx.doi.org/10.4061/2011/212485 |
| spellingShingle | Serena Amici Maurizio Paciaroni Giancarlo Agnelli Valeria Caso Gene-Drug Interaction in Stroke Stroke Research and Treatment |
| title | Gene-Drug Interaction in Stroke |
| title_full | Gene-Drug Interaction in Stroke |
| title_fullStr | Gene-Drug Interaction in Stroke |
| title_full_unstemmed | Gene-Drug Interaction in Stroke |
| title_short | Gene-Drug Interaction in Stroke |
| title_sort | gene drug interaction in stroke |
| url | http://dx.doi.org/10.4061/2011/212485 |
| work_keys_str_mv | AT serenaamici genedruginteractioninstroke AT mauriziopaciaroni genedruginteractioninstroke AT giancarloagnelli genedruginteractioninstroke AT valeriacaso genedruginteractioninstroke |