Ionic Liquid Aided [11C]CO Fixation for Synthesis of 11C‐carbonyls
Abstract Tributyl(ethyl)phosphonium oxopentenolate ([P4442][Pen]) is an ionic liquid developed to capture CO and has shown ability to catalyze carbonylation reactions in organic chemistry. Carbon‐11 (11C, t1/2=20.4 min) labeled CO is a highly versatile building block for the synthesis of positron em...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2025-07-01
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| Series: | ChemistryOpen |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/open.202400410 |
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| Summary: | Abstract Tributyl(ethyl)phosphonium oxopentenolate ([P4442][Pen]) is an ionic liquid developed to capture CO and has shown ability to catalyze carbonylation reactions in organic chemistry. Carbon‐11 (11C, t1/2=20.4 min) labeled CO is a highly versatile building block for the synthesis of positron emission tomography (PET) radiotracers that are applied for medical imaging. The use of [11C]CO is limited by its low solubility in organic solvents. Herein, we report a proof‐of‐concept study evaluating a new method to prepare 11C‐labeled amides, ureas and carbamates via reaction of [11C]CO in [P4442][Pen] and applied for fully automated radiosyntheses of Bruton's tyrosine kinase inhibitors, [11C]evobrutinib and [11C]ibrutinib. |
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| ISSN: | 2191-1363 |