Erbin interacts with NHERF1 and Ezrin to stabilize a membrane ErbB2 signaling complex in HER2-positive breast cancer

Erbin interacts with NHERF1 and Ezrin to stabilize a membrane ErbB2 signaling complex in HER2-positive breast cancer

Abstract Approximately 20% of breast cancers overexpress ErbB2/HER2/Neu, a receptor tyrosine kinase. Our previous studies demonstrated that HER2 interacts with the calcium pump, PMCA2, and the scaffolding molecules, NHERF1 and Ezrin to stabilize HER2/HSP90 interactions and contribute to the retentio...

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Bibliographic Details
Main Authors: Jaekwang Jeong, Kwangmin Yoo, Jongwon Lee, Jae Hun Shin, Jungmin Choi, John Wysolmerski
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Breast Cancer Research
Subjects:
Erbin
HER2
NHERF1
Ezrin
Apical/basal polarity
HSP90
Online Access:https://doi.org/10.1186/s13058-025-02025-6
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