Metformin modifed UiO-66-NH2 as a super basic nanocatalyst for the four component synthesis of dihydropyridines
Abstract This study presents the synthesis of a novel metal-organic framework (UiO-66-NH-nBut-Met) using PSM (post-synthetic modification) of UiO-66-NH2 with metformin. The formation of UiO-66-NH-nBut-Met nanocatalyst was confirmed using analytical techniques, including BET, TEM, FT-IR, XRD, TGA, SE...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-11840-y |
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| Summary: | Abstract This study presents the synthesis of a novel metal-organic framework (UiO-66-NH-nBut-Met) using PSM (post-synthetic modification) of UiO-66-NH2 with metformin. The formation of UiO-66-NH-nBut-Met nanocatalyst was confirmed using analytical techniques, including BET, TEM, FT-IR, XRD, TGA, SEM, elemental mapping, and CHN analyses. Subsequently, the catalytic performance of the UiO-66-NH-nBut-Met was explored in the four-component synthesis of 1,4-dihydropyridines. The obtained results demonstrated remarkable productivity (excellent yields: 91–97%), within short reaction times (< 7 min) in solvent-free conditions. The enhancement of the catalytic activity of UiO-66-NH-nBut-Met compared to UiO-66-NH2 can be attributed to metformin (N, N-dimethyl biguanidine) containing polydentate nitrogen donor ligands, as a super-basic agent. Furthermore, the catalyst demonstrated remarkable recyclability, maintaining high catalytic activity even after five consecutive runs. |
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| ISSN: | 2045-2322 |