Sodium alginate/κ-carrageenan films for mupirocin dermal delivery
Aim: The chronicity of injuries is also a public health problem, and it is necessary to develop and apply new materials to promote more satisfactory results in the wound healing. Thus, this study aims to develop natural polymer films based on a combination of κ-carrageenan and sodium alginate, cross...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Open Exploration Publishing Inc.
2025-01-01
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| Series: | Exploration of BioMat-X |
| Subjects: | |
| Online Access: | https://www.explorationpub.com/uploads/Article/A101326/101326.pdf |
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| Summary: | Aim: The chronicity of injuries is also a public health problem, and it is necessary to develop and apply new materials to promote more satisfactory results in the wound healing. Thus, this study aims to develop natural polymer films based on a combination of κ-carrageenan and sodium alginate, crosslinked with Zn2+, for the controlled delivery of mupirocin (MUP). Methods: Vibrational spectroscopy (Raman and infrared spectroscopies) was used to characterize the chemical structure and crosslinking process. Micro-Raman imaging and scanning electron microscopy were employed to observe the spatial distribution of the polymers and morphology of the samples, respectively. The uniformity (in terms of mass, thickness, and MUP concentration) of the films, MUP release kinetics, and their bactericidal activity were subjected to analysis. Results: The films exhibited good uniformity in terms of thickness, mass, and quantity of MUP. However, the percentage of antibiotics was lower than that added, indicating losses during the film production process. Swelling and release kinetic studies indicated good swelling capacity of the films and controlled drug delivery process. The antibacterial activity of the films was determined against Staphylococcus aureus, Escherichia coli, Staphylococcus epidermidis, and Pseudomonas aeruginosa using the zone of inhibition method. All films produced showed activity against the growth of these bacteria. Conclusions: The results illustrate the potential of employing κ-carrageenan and sodium alginate in the fabrication of polymeric films for the regulated release of MUP, with the aim of developing wound dressings that can improve wound healing outcomes. |
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| ISSN: | 2996-9476 |