The Role of HIF-1α in Atrial Fibrillation: Recent Advances and Therapeutic Potentials
The steady increase in life expectancy throughout the world is contributing to an increased incidence of atrial fibrillation (AF), which imposes a significant socioeconomic toll on affected patients and societies. The mechanisms underlying atrial fibrillation are multifaceted and vary among individu...
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| Format: | Article |
| Language: | English |
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IMR Press
2025-02-01
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| Series: | Reviews in Cardiovascular Medicine |
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| Online Access: | https://www.imrpress.com/journal/RCM/26/2/10.31083/RCM26787 |
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| author | Feng Zhou Jia-Bin Zhou Tian-Peng Wei Dan Wu Ru-Xing Wang |
| author_facet | Feng Zhou Jia-Bin Zhou Tian-Peng Wei Dan Wu Ru-Xing Wang |
| author_sort | Feng Zhou |
| collection | DOAJ |
| description | The steady increase in life expectancy throughout the world is contributing to an increased incidence of atrial fibrillation (AF), which imposes a significant socioeconomic toll on affected patients and societies. The mechanisms underlying atrial fibrillation are multifaceted and vary among individuals. Hypoxia is a process that is closely linked to AF onset and progression. Hypoxia-inducible factor 1-alpha (HIF-1α) is a transcription factor that serves as a key regulator of oxygen homeostasis within cells through its activation under hypoxic conditions and subsequently coordinates various pathophysiological responses. High levels of HIF-1α expression are evident in AF patients, and facilitate the progression from persistent AF to permanent AF. Thus, HIF-1α may serve as a promising target for novel therapeutic strategies aimed at the prevention and treatment of AF. This review provides an overview and synthesis of recent studies probing the relationship between HIF-1α and AF, providing a foundation for future studies and the development targeted drug therapies. |
| format | Article |
| id | doaj-art-57ce1b48250f48aca0bc90e8ae2b01bc |
| institution | OA Journals |
| issn | 1530-6550 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj-art-57ce1b48250f48aca0bc90e8ae2b01bc2025-08-20T02:11:13ZengIMR PressReviews in Cardiovascular Medicine1530-65502025-02-012622678710.31083/RCM26787S1530-6550(24)01653-3The Role of HIF-1α in Atrial Fibrillation: Recent Advances and Therapeutic PotentialsFeng Zhou0Jia-Bin Zhou1Tian-Peng Wei2Dan Wu3Ru-Xing Wang4Department of Cardiology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, 214023 Wuxi, Jiangsu, ChinaDepartment of Cardiology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, 214023 Wuxi, Jiangsu, ChinaDepartment of Cardiology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, 214023 Wuxi, Jiangsu, ChinaDepartment of Cardiology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, 214023 Wuxi, Jiangsu, ChinaDepartment of Cardiology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, 214023 Wuxi, Jiangsu, ChinaThe steady increase in life expectancy throughout the world is contributing to an increased incidence of atrial fibrillation (AF), which imposes a significant socioeconomic toll on affected patients and societies. The mechanisms underlying atrial fibrillation are multifaceted and vary among individuals. Hypoxia is a process that is closely linked to AF onset and progression. Hypoxia-inducible factor 1-alpha (HIF-1α) is a transcription factor that serves as a key regulator of oxygen homeostasis within cells through its activation under hypoxic conditions and subsequently coordinates various pathophysiological responses. High levels of HIF-1α expression are evident in AF patients, and facilitate the progression from persistent AF to permanent AF. Thus, HIF-1α may serve as a promising target for novel therapeutic strategies aimed at the prevention and treatment of AF. This review provides an overview and synthesis of recent studies probing the relationship between HIF-1α and AF, providing a foundation for future studies and the development targeted drug therapies.https://www.imrpress.com/journal/RCM/26/2/10.31083/RCM26787hypoxia-inducible factor 1-alphaatrial fibrillationmechanism |
| spellingShingle | Feng Zhou Jia-Bin Zhou Tian-Peng Wei Dan Wu Ru-Xing Wang The Role of HIF-1α in Atrial Fibrillation: Recent Advances and Therapeutic Potentials Reviews in Cardiovascular Medicine hypoxia-inducible factor 1-alpha atrial fibrillation mechanism |
| title | The Role of HIF-1α in Atrial Fibrillation: Recent Advances and Therapeutic Potentials |
| title_full | The Role of HIF-1α in Atrial Fibrillation: Recent Advances and Therapeutic Potentials |
| title_fullStr | The Role of HIF-1α in Atrial Fibrillation: Recent Advances and Therapeutic Potentials |
| title_full_unstemmed | The Role of HIF-1α in Atrial Fibrillation: Recent Advances and Therapeutic Potentials |
| title_short | The Role of HIF-1α in Atrial Fibrillation: Recent Advances and Therapeutic Potentials |
| title_sort | role of hif 1α in atrial fibrillation recent advances and therapeutic potentials |
| topic | hypoxia-inducible factor 1-alpha atrial fibrillation mechanism |
| url | https://www.imrpress.com/journal/RCM/26/2/10.31083/RCM26787 |
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