Evaluation of inflammation in obesity and chronic kidney disease with hemogram parameters
Aim: Chronic inflammation is involved in the pathogenesis of both obesity and chronic kidney disease (CKD). We aimed to evaluate the parameters derived from complete blood count (CBC) as inflammatory markers in obese patients and obese CKD patients.Methods: Individuals enrolled in the study were div...
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| Format: | Article |
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Alanya Alaaddin Keykubat University
2021-12-01
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| Series: | Acta Medica Alanya |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/1789596 |
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| author | İlter Bozacı Erhan Tatar |
| author_facet | İlter Bozacı Erhan Tatar |
| author_sort | İlter Bozacı |
| collection | DOAJ |
| description | Aim: Chronic inflammation is involved in the pathogenesis of both obesity and chronic kidney disease (CKD). We aimed to evaluate the parameters derived from complete blood count (CBC) as inflammatory markers in obese patients and obese CKD patients.Methods: Individuals enrolled in the study were divided into three groups. Group-1 was composed of obese patients; group-2 was composed of obese CKD patients and group-3 was composed of healthy individuals as the control group. This study was conducted at a training and research hospital over 6 months period.Results: Forty-one patients were in group-1; 41 patients were in group-2 and 22 individuals were in group-3. White blood cell count (WBC) was significantly higher in group-1 and group-2 compared with group-3 (7,5±1,4 x103/µL vs 8,4±2,4 x103/µL vs 6,5±1,3 x103/µL, respectively, p<0.001) and neutrophile to lymphocyte ratio (NLR) was significantly higher in group-1 and group-2 compared with group-3 (1,9±0,7 vs 2,5±1,5 vs 1,7±0,4, respectively, p<0.001). NLR and WBC was found positively correlated with systolic blood pressure, urea, creatinine, uric acid, whereas negatively correlated with estimated glomerular filtration rate.Conclusion: It is important to determine significant results in CBC derived markers that are widely used in routine clinical practice as inflammatory markers. |
| format | Article |
| id | doaj-art-57cd606cb25b475dbe9331316922320b |
| institution | Kabale University |
| issn | 2587-0319 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Alanya Alaaddin Keykubat University |
| record_format | Article |
| series | Acta Medica Alanya |
| spelling | doaj-art-57cd606cb25b475dbe9331316922320b2025-08-20T03:53:22ZengAlanya Alaaddin Keykubat UniversityActa Medica Alanya2587-03192021-12-015327628110.30565/medalanya.943299727Evaluation of inflammation in obesity and chronic kidney disease with hemogram parametersİlter Bozacı0https://orcid.org/0000-0001-7535-9403Erhan Tatar1https://orcid.org/0000-0002-5068-4231Manisa Şehir HastanesiSAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İZMİR BOZYAKA SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİAim: Chronic inflammation is involved in the pathogenesis of both obesity and chronic kidney disease (CKD). We aimed to evaluate the parameters derived from complete blood count (CBC) as inflammatory markers in obese patients and obese CKD patients.Methods: Individuals enrolled in the study were divided into three groups. Group-1 was composed of obese patients; group-2 was composed of obese CKD patients and group-3 was composed of healthy individuals as the control group. This study was conducted at a training and research hospital over 6 months period.Results: Forty-one patients were in group-1; 41 patients were in group-2 and 22 individuals were in group-3. White blood cell count (WBC) was significantly higher in group-1 and group-2 compared with group-3 (7,5±1,4 x103/µL vs 8,4±2,4 x103/µL vs 6,5±1,3 x103/µL, respectively, p<0.001) and neutrophile to lymphocyte ratio (NLR) was significantly higher in group-1 and group-2 compared with group-3 (1,9±0,7 vs 2,5±1,5 vs 1,7±0,4, respectively, p<0.001). NLR and WBC was found positively correlated with systolic blood pressure, urea, creatinine, uric acid, whereas negatively correlated with estimated glomerular filtration rate.Conclusion: It is important to determine significant results in CBC derived markers that are widely used in routine clinical practice as inflammatory markers.https://dergipark.org.tr/tr/download/article-file/1789596inflammationrenal insufficiencyblood cell count.enflamasyonböbrek yetmezliğikan hücre sayımı |
| spellingShingle | İlter Bozacı Erhan Tatar Evaluation of inflammation in obesity and chronic kidney disease with hemogram parameters Acta Medica Alanya inflammation renal insufficiency blood cell count. enflamasyon böbrek yetmezliği kan hücre sayımı |
| title | Evaluation of inflammation in obesity and chronic kidney disease with hemogram parameters |
| title_full | Evaluation of inflammation in obesity and chronic kidney disease with hemogram parameters |
| title_fullStr | Evaluation of inflammation in obesity and chronic kidney disease with hemogram parameters |
| title_full_unstemmed | Evaluation of inflammation in obesity and chronic kidney disease with hemogram parameters |
| title_short | Evaluation of inflammation in obesity and chronic kidney disease with hemogram parameters |
| title_sort | evaluation of inflammation in obesity and chronic kidney disease with hemogram parameters |
| topic | inflammation renal insufficiency blood cell count. enflamasyon böbrek yetmezliği kan hücre sayımı |
| url | https://dergipark.org.tr/tr/download/article-file/1789596 |
| work_keys_str_mv | AT ilterbozacı evaluationofinflammationinobesityandchronickidneydiseasewithhemogramparameters AT erhantatar evaluationofinflammationinobesityandchronickidneydiseasewithhemogramparameters |