Influence of Genetic Polymorphisms on the Age at Cancer Diagnosis in a Homogenous Lynch Syndrome Cohort of Individuals Carrying the <i>MLH1</i>:c.1528C>T South African Founder Variant

Influence of Genetic Polymorphisms on the Age at Cancer Diagnosis in a Homogenous Lynch Syndrome Cohort of Individuals Carrying the <i>MLH1</i>:c.1528C>T South African Founder Variant

<b>Background:</b> High variability in the age at cancer diagnosis in Lynch syndrome (LS) patients is widely observed, even among relatives with the same germline pathogenic variant (PV) in the mismatch repair (MMR) genes. Genetic polymorphisms and lifestyle factors are thought to contri...

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Bibliographic Details
Main Authors: Lutricia Ndou, Ramadhani Chambuso, Ursula Algar, Paul Goldberg, Adam Boutall, Raj Ramesar
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Biomedicines
Subjects:
Lynch syndrome
age at cancer diagnosis
colorectal cancer
Lynch syndrome-associated cancer
extracolonic cancer
genetic polymorphisms
Online Access:https://www.mdpi.com/2227-9059/12/10/2201
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