Lymph node ratio: prognostic value in laryngeal cancer after primary total laryngectomy
Objectives: To evaluate Lymph node ratio (LNR) as a predictor for survival and recurrence of laryngeal cancer with metastatic lymph nodes (pN+). Study design: This retrospective study included patients who underwent primary laryngectomy combined with bilateral neck dissection, between October/20...
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| Format: | Article |
| Language: | English |
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Portuguese Society of Otolaryngology and Head and Neck Surgery
2024-09-01
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| Series: | Revista Portuguesa Otorrinolaringologia e Cirurgia de Cabeça e Pescoço |
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| Online Access: | https://journalsporl.com/index.php/sporl/article/view/2189 |
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| author | Mónica Teixeira Joana Freitas Rebelo Elisabete Torres Branco Nuno Medeiros Sandra Alves Pedro Oliveira |
| author_facet | Mónica Teixeira Joana Freitas Rebelo Elisabete Torres Branco Nuno Medeiros Sandra Alves Pedro Oliveira |
| author_sort | Mónica Teixeira |
| collection | DOAJ |
| description |
Objectives: To evaluate Lymph node ratio (LNR) as a predictor for survival and recurrence of laryngeal cancer with metastatic lymph nodes (pN+).
Study design: This retrospective study included patients who underwent primary laryngectomy combined with bilateral neck dissection, between October/2010 and April/2023.
Results: A total of 73 patients were included. Among pN+ patients (n=37;50.7%), those with disease recurrence (n=16;43.2%) exhibited a higher median LNR (0.159 versus 0.060), p=0.007. ROC curve analysis showed that LNR>0.063 predicted recurrence (sensitivity 87%;specificity 48%). Moreover, multivariate analysis confirmed LNR>0.063 as an independent predictor of disease recurrence, after controlling for potential confounders, namely age, extracapsular spread, resection margin and pathological T category, (HR=6.58; p=0.049). Finally, high LNR (>0.063) was associated with cancer-specific death (OR=8.64; p=0.008) in pN+ patients.
Conclusion: Our findings highlight that patients with LNR>0.063 are more likely to have aggressive disease, suggesting LNR as a significant prognostic factor complementing TNM staging in pN+ laryngeal cancer.
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| format | Article |
| id | doaj-art-57b65ec11ed24dd9b9d8ea03e20782e9 |
| institution | Kabale University |
| issn | 2184-6499 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Portuguese Society of Otolaryngology and Head and Neck Surgery |
| record_format | Article |
| series | Revista Portuguesa Otorrinolaringologia e Cirurgia de Cabeça e Pescoço |
| spelling | doaj-art-57b65ec11ed24dd9b9d8ea03e20782e92025-08-20T03:30:09ZengPortuguese Society of Otolaryngology and Head and Neck SurgeryRevista Portuguesa Otorrinolaringologia e Cirurgia de Cabeça e Pescoço2184-64992024-09-0162310.34631/sporl.2189Lymph node ratio: prognostic value in laryngeal cancer after primary total laryngectomyMónica Teixeira0Joana Freitas Rebelo1Elisabete Torres Branco2Nuno Medeiros3Sandra Alves4Pedro Oliveira5Unidade Local de Saúde de Gaia/Espinho, EPE, PortugalUnidade Local de Saúde de Gaia/Espinho, EPE, PortugalUnidade Local de Saúde de Gaia/Espinho, EPE, PortugalUnidade Local de Saúde de Gaia/Espinho, EPE, PortugalUnidade Local de Saúde de Gaia/Espinho, EPE, PortugalUnidade Local de Saúde de Gaia/Espinho, EPE, Portugal Objectives: To evaluate Lymph node ratio (LNR) as a predictor for survival and recurrence of laryngeal cancer with metastatic lymph nodes (pN+). Study design: This retrospective study included patients who underwent primary laryngectomy combined with bilateral neck dissection, between October/2010 and April/2023. Results: A total of 73 patients were included. Among pN+ patients (n=37;50.7%), those with disease recurrence (n=16;43.2%) exhibited a higher median LNR (0.159 versus 0.060), p=0.007. ROC curve analysis showed that LNR>0.063 predicted recurrence (sensitivity 87%;specificity 48%). Moreover, multivariate analysis confirmed LNR>0.063 as an independent predictor of disease recurrence, after controlling for potential confounders, namely age, extracapsular spread, resection margin and pathological T category, (HR=6.58; p=0.049). Finally, high LNR (>0.063) was associated with cancer-specific death (OR=8.64; p=0.008) in pN+ patients. Conclusion: Our findings highlight that patients with LNR>0.063 are more likely to have aggressive disease, suggesting LNR as a significant prognostic factor complementing TNM staging in pN+ laryngeal cancer. https://journalsporl.com/index.php/sporl/article/view/2189Lymph Node RatioLaryngeal cancerprognostic factorsNeck Dissection |
| spellingShingle | Mónica Teixeira Joana Freitas Rebelo Elisabete Torres Branco Nuno Medeiros Sandra Alves Pedro Oliveira Lymph node ratio: prognostic value in laryngeal cancer after primary total laryngectomy Revista Portuguesa Otorrinolaringologia e Cirurgia de Cabeça e Pescoço Lymph Node Ratio Laryngeal cancer prognostic factors Neck Dissection |
| title | Lymph node ratio: prognostic value in laryngeal cancer after primary total laryngectomy |
| title_full | Lymph node ratio: prognostic value in laryngeal cancer after primary total laryngectomy |
| title_fullStr | Lymph node ratio: prognostic value in laryngeal cancer after primary total laryngectomy |
| title_full_unstemmed | Lymph node ratio: prognostic value in laryngeal cancer after primary total laryngectomy |
| title_short | Lymph node ratio: prognostic value in laryngeal cancer after primary total laryngectomy |
| title_sort | lymph node ratio prognostic value in laryngeal cancer after primary total laryngectomy |
| topic | Lymph Node Ratio Laryngeal cancer prognostic factors Neck Dissection |
| url | https://journalsporl.com/index.php/sporl/article/view/2189 |
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