Detection of circulating tumor cells in peripheral blood of patients with tongue squamous cell carcinoma and its relationship with clinical features and prognosis: a retrospective study
Abstract Background Circulating tumor cells (CTCs) are a promising biomarker for assessment of prognosis. The study was to analyse the relationship between preoperative and postoperative peripheral blood CTC and clinical features and prognosis in patients with tongue squamous cell carcinoma (TSCC)....
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| Format: | Article |
| Language: | English |
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Springer
2024-11-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-024-01583-z |
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| author | Ningbo Geng Weiyi Lin Dandan Zhang Wei Cao Chongjin Feng Shan Chen |
| author_facet | Ningbo Geng Weiyi Lin Dandan Zhang Wei Cao Chongjin Feng Shan Chen |
| author_sort | Ningbo Geng |
| collection | DOAJ |
| description | Abstract Background Circulating tumor cells (CTCs) are a promising biomarker for assessment of prognosis. The study was to analyse the relationship between preoperative and postoperative peripheral blood CTC and clinical features and prognosis in patients with tongue squamous cell carcinoma (TSCC). Methods 85 with TSCC and 30 tongues with benign disease who underwent surgical treatment from May 2016 to May 2023 were retrospectively analysed. CTC testing was performed twice for TSCC group before and after surgery and only before the surgery for the benign disease group, only one test was performed before surgery.The association of CTCs with clinical features and progression-free survival (PFS) was also analyzed. Results The positive rates of CTCs in patients with TSCC were 90.6% before treatment and 72.9% after treatment, respectively. CTCs were not detected in patients with benign disease group before treatment. There was no significant difference in the number of CTCs before and after treatment in patients with disease progression (P > 0.05). However, the number of CTCs after treatment in patients with disease remission (DR) and stable disease (SD) was significantly lower than before treatment, and the difference was statistically significant (P < 0.05). The results of the log-rank test demonstrated that the postoperative CTC was associated with the PFS (P < 0.05), whereas the preoperative CTC was not related to the PFS. The Cox proportional hazard regression model indicated that postoperative CTC and lymph node metastasis were independent risk factors. Conclusions Postoperative CTCs may be an independent risk factor for a poor prognosis in patients with TSCC and CTC may serve as a valuable biomarker for prognostic monitoring for TSCC patients. |
| format | Article |
| id | doaj-art-57aed53d274049bd87c9c4b9fbc40b33 |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-57aed53d274049bd87c9c4b9fbc40b332024-11-24T12:31:47ZengSpringerDiscover Oncology2730-60112024-11-0115111010.1007/s12672-024-01583-zDetection of circulating tumor cells in peripheral blood of patients with tongue squamous cell carcinoma and its relationship with clinical features and prognosis: a retrospective studyNingbo Geng0Weiyi Lin1Dandan Zhang2Wei Cao3Chongjin Feng4Shan Chen5Department of Stomatology, The First Affiliated Hospital of Sun Yat-Sen UniversityDepartment of Stomatology, The First Affiliated Hospital of Sun Yat-Sen UniversityDepartment of Stomatology, The First Affiliated Hospital of Sun Yat-Sen UniversityDepartment of Oral Surgery, Shenzhen Traditional Chinese Medicine HospitalDepartment of Stomatology, The First Affiliated Hospital of Sun Yat-Sen UniversityDepartment of Stomatology, The First Affiliated Hospital of Sun Yat-Sen UniversityAbstract Background Circulating tumor cells (CTCs) are a promising biomarker for assessment of prognosis. The study was to analyse the relationship between preoperative and postoperative peripheral blood CTC and clinical features and prognosis in patients with tongue squamous cell carcinoma (TSCC). Methods 85 with TSCC and 30 tongues with benign disease who underwent surgical treatment from May 2016 to May 2023 were retrospectively analysed. CTC testing was performed twice for TSCC group before and after surgery and only before the surgery for the benign disease group, only one test was performed before surgery.The association of CTCs with clinical features and progression-free survival (PFS) was also analyzed. Results The positive rates of CTCs in patients with TSCC were 90.6% before treatment and 72.9% after treatment, respectively. CTCs were not detected in patients with benign disease group before treatment. There was no significant difference in the number of CTCs before and after treatment in patients with disease progression (P > 0.05). However, the number of CTCs after treatment in patients with disease remission (DR) and stable disease (SD) was significantly lower than before treatment, and the difference was statistically significant (P < 0.05). The results of the log-rank test demonstrated that the postoperative CTC was associated with the PFS (P < 0.05), whereas the preoperative CTC was not related to the PFS. The Cox proportional hazard regression model indicated that postoperative CTC and lymph node metastasis were independent risk factors. Conclusions Postoperative CTCs may be an independent risk factor for a poor prognosis in patients with TSCC and CTC may serve as a valuable biomarker for prognostic monitoring for TSCC patients.https://doi.org/10.1007/s12672-024-01583-zCirculating tumour cellsSquamous cell carcinoma of the tonguePrognosisNegative enrichment |
| spellingShingle | Ningbo Geng Weiyi Lin Dandan Zhang Wei Cao Chongjin Feng Shan Chen Detection of circulating tumor cells in peripheral blood of patients with tongue squamous cell carcinoma and its relationship with clinical features and prognosis: a retrospective study Discover Oncology Circulating tumour cells Squamous cell carcinoma of the tongue Prognosis Negative enrichment |
| title | Detection of circulating tumor cells in peripheral blood of patients with tongue squamous cell carcinoma and its relationship with clinical features and prognosis: a retrospective study |
| title_full | Detection of circulating tumor cells in peripheral blood of patients with tongue squamous cell carcinoma and its relationship with clinical features and prognosis: a retrospective study |
| title_fullStr | Detection of circulating tumor cells in peripheral blood of patients with tongue squamous cell carcinoma and its relationship with clinical features and prognosis: a retrospective study |
| title_full_unstemmed | Detection of circulating tumor cells in peripheral blood of patients with tongue squamous cell carcinoma and its relationship with clinical features and prognosis: a retrospective study |
| title_short | Detection of circulating tumor cells in peripheral blood of patients with tongue squamous cell carcinoma and its relationship with clinical features and prognosis: a retrospective study |
| title_sort | detection of circulating tumor cells in peripheral blood of patients with tongue squamous cell carcinoma and its relationship with clinical features and prognosis a retrospective study |
| topic | Circulating tumour cells Squamous cell carcinoma of the tongue Prognosis Negative enrichment |
| url | https://doi.org/10.1007/s12672-024-01583-z |
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