Preterm Birth and Cardiometabolic Health Trajectories From Birth to Adulthood: The Avon Longitudinal Study of Parents and Children
Background Adults who were born prematurely (<37 weeks’ gestation) are at increased cardiovascular disease risk, but it is unclear when in the life course this risk emerges. Our aim was to compare trajectories of multiple cardiometabolic risk factors from childhood to early adulthood between thos...
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| Format: | Article |
| Language: | English |
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Wiley
2025-02-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
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| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.123.030823 |
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| author | Gemma L. Clayton Laura D. Howe Linda M. O'Keeffe Adam J. Lewandowski Deborah A. Lawlor Abigail Fraser |
| author_facet | Gemma L. Clayton Laura D. Howe Linda M. O'Keeffe Adam J. Lewandowski Deborah A. Lawlor Abigail Fraser |
| author_sort | Gemma L. Clayton |
| collection | DOAJ |
| description | Background Adults who were born prematurely (<37 weeks’ gestation) are at increased cardiovascular disease risk, but it is unclear when in the life course this risk emerges. Our aim was to compare trajectories of multiple cardiometabolic risk factors from childhood to early adulthood between those who had and had not been born preterm. Methods and Results Multilevel models were used to compare trajectories from early childhood (<9 years) to age 25 years of body mass index, fat and lean mass, systolic and diastolic blood pressure, lipids, glucose, and insulin, between individuals born preterm (N=311–676; range, 25–36 weeks’ gestation) and term (N=4973–10 534) in a UK birth cohort study. We also investigated gestational age as a continuum. In children born preterm (versus term), systolic and diastolic blood pressures were higher at age 7 years (mean predicted differences, 0.7 [95% CI, −0.2 to 1.6] mm Hg and 0.6 [95% CI, −0.04 to 1.3] mm Hg, respectively). By age 18 years, the difference in systolic blood pressure persisted (1.9 [95% CI, 0.8–3.1] mm Hg) and in diastolic blood pressure (0.1 [95% CI, −0.7 to 1.0 mm Hg]) disappeared. By age 25 years, this difference in systolic blood pressure began to attenuate towards the null (0.9 [95% CI, −0.5 to 2.3] mm Hg). Participants born preterm (versus term) had lower body mass index between ages 7 and 18 years, but by age 25 years, there was no difference. Fat and lean mass trajectories were consistent with body mass index. High‐density lipoprotein cholesterol was higher and triglycerides lower at birth, in those born preterm, but this difference also disappeared by age 25 years. There was no evidence of differences in glucose and insulin. Conclusions Few, modest differences in cardiometabolic health were found in those born preterm versus term. All disappeared by age 25 years, except the small difference in systolic blood pressure. Longer follow‐up is needed to establish if and when cardiometabolic health trajectories diverge between these 2 groups. |
| format | Article |
| id | doaj-art-579c630288b24975969ca6520aee439b |
| institution | Kabale University |
| issn | 2047-9980 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-579c630288b24975969ca6520aee439b2025-02-04T11:00:01ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802025-02-0114310.1161/JAHA.123.030823Preterm Birth and Cardiometabolic Health Trajectories From Birth to Adulthood: The Avon Longitudinal Study of Parents and ChildrenGemma L. Clayton0Laura D. Howe1Linda M. O'Keeffe2Adam J. Lewandowski3Deborah A. Lawlor4Abigail Fraser5Medical Research Council Integrative Epidemiology Unit at the University of Bristol Bristol UKMedical Research Council Integrative Epidemiology Unit at the University of Bristol Bristol UKMedical Research Council Integrative Epidemiology Unit at the University of Bristol Bristol UKNuffield Department of Population Health University of Oxford Oxford UKMedical Research Council Integrative Epidemiology Unit at the University of Bristol Bristol UKMedical Research Council Integrative Epidemiology Unit at the University of Bristol Bristol UKBackground Adults who were born prematurely (<37 weeks’ gestation) are at increased cardiovascular disease risk, but it is unclear when in the life course this risk emerges. Our aim was to compare trajectories of multiple cardiometabolic risk factors from childhood to early adulthood between those who had and had not been born preterm. Methods and Results Multilevel models were used to compare trajectories from early childhood (<9 years) to age 25 years of body mass index, fat and lean mass, systolic and diastolic blood pressure, lipids, glucose, and insulin, between individuals born preterm (N=311–676; range, 25–36 weeks’ gestation) and term (N=4973–10 534) in a UK birth cohort study. We also investigated gestational age as a continuum. In children born preterm (versus term), systolic and diastolic blood pressures were higher at age 7 years (mean predicted differences, 0.7 [95% CI, −0.2 to 1.6] mm Hg and 0.6 [95% CI, −0.04 to 1.3] mm Hg, respectively). By age 18 years, the difference in systolic blood pressure persisted (1.9 [95% CI, 0.8–3.1] mm Hg) and in diastolic blood pressure (0.1 [95% CI, −0.7 to 1.0 mm Hg]) disappeared. By age 25 years, this difference in systolic blood pressure began to attenuate towards the null (0.9 [95% CI, −0.5 to 2.3] mm Hg). Participants born preterm (versus term) had lower body mass index between ages 7 and 18 years, but by age 25 years, there was no difference. Fat and lean mass trajectories were consistent with body mass index. High‐density lipoprotein cholesterol was higher and triglycerides lower at birth, in those born preterm, but this difference also disappeared by age 25 years. There was no evidence of differences in glucose and insulin. Conclusions Few, modest differences in cardiometabolic health were found in those born preterm versus term. All disappeared by age 25 years, except the small difference in systolic blood pressure. Longer follow‐up is needed to establish if and when cardiometabolic health trajectories diverge between these 2 groups.https://www.ahajournals.org/doi/10.1161/JAHA.123.030823ALSPACbirth weightcardiometaboliccardiovascularpreterm |
| spellingShingle | Gemma L. Clayton Laura D. Howe Linda M. O'Keeffe Adam J. Lewandowski Deborah A. Lawlor Abigail Fraser Preterm Birth and Cardiometabolic Health Trajectories From Birth to Adulthood: The Avon Longitudinal Study of Parents and Children Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease ALSPAC birth weight cardiometabolic cardiovascular preterm |
| title | Preterm Birth and Cardiometabolic Health Trajectories From Birth to Adulthood: The Avon Longitudinal Study of Parents and Children |
| title_full | Preterm Birth and Cardiometabolic Health Trajectories From Birth to Adulthood: The Avon Longitudinal Study of Parents and Children |
| title_fullStr | Preterm Birth and Cardiometabolic Health Trajectories From Birth to Adulthood: The Avon Longitudinal Study of Parents and Children |
| title_full_unstemmed | Preterm Birth and Cardiometabolic Health Trajectories From Birth to Adulthood: The Avon Longitudinal Study of Parents and Children |
| title_short | Preterm Birth and Cardiometabolic Health Trajectories From Birth to Adulthood: The Avon Longitudinal Study of Parents and Children |
| title_sort | preterm birth and cardiometabolic health trajectories from birth to adulthood the avon longitudinal study of parents and children |
| topic | ALSPAC birth weight cardiometabolic cardiovascular preterm |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.123.030823 |
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