Distinct mechanisms of inadequate erythropoiesis induced by tumor necrosis factor alpha or malarial pigment.

The role of infection in erythropoietic dysfunction is poorly understood. In children with P. falciparum malaria, the by-product of hemoglobin digestion in infected red cells (hemozoin) is associated with the severity of anemia which is independent of circulating levels of the inflammatory cytokine...

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Bibliographic Details
Main Authors: Abigail A Lamikanra, Alison T Merryweather-Clarke, Alex J Tipping, David J Roberts
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0119836
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