Abnormal cerebellar activity and connectivity alterations of the cerebellar-limbic system in post-stroke cognitive impairment: a study based on resting state functional magnetic resonance imaging
BackgroundStroke is an important cause of cognitive impairment. Post-stroke cognitive impairment (PSCI) is a prevalent psychiatric disorder following stroke. However, the effects of PSCI on the cerebellum remain mostly unknown.MethodsA total of 31 PSCI patients and 31 patients without cognitive impa...
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Frontiers Media S.A.
2025-03-01
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| author | Haiyi Zhang Juan Lu Lu Zhang Jidan Hu Jiajun Yue Yunhan Ma Qi Yao Pingping Jie Min Fan Min Fan Min Fan Jiliang Fang Jie Zhao |
| author_facet | Haiyi Zhang Juan Lu Lu Zhang Jidan Hu Jiajun Yue Yunhan Ma Qi Yao Pingping Jie Min Fan Min Fan Min Fan Jiliang Fang Jie Zhao |
| author_sort | Haiyi Zhang |
| collection | DOAJ |
| description | BackgroundStroke is an important cause of cognitive impairment. Post-stroke cognitive impairment (PSCI) is a prevalent psychiatric disorder following stroke. However, the effects of PSCI on the cerebellum remain mostly unknown.MethodsA total of 31 PSCI patients and 31 patients without cognitive impairment after stroke were included in this study. The Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) were administered to all participants. Analyses of ALFF, fALFF, and ReHo were employed to investigate alterations in brain neuronal activity, while limbic connectivity analysis was utilized to reflect changes within the abnormal connections within brain regions.ResultsWe found that ALFF values were increased in Cerebelum_7b_R, Cerebelum_Crus1_L. fALFF values were increased in Vermis_3. The ReHo values were increased in Cerebelum_8_R, Cerebelum_Crus2_R, Cerebelum_Crus1_L. The functional connection between Frontal_Mid_Orb_L and Cerebelum_Crus2_R brain regions was decreased. The functional connection between Hippocampus_L and Cerebelum_Crus2_R brain regions was decreased. The functional connection between Vermis_3 and Frontal_Med_Orb_L brain regions was decreased.ConclusionThe severity of cognitive impairment may influence the extent of functional connectivity disruption between the cerebellum and the limbic system. Furthermore, atypical alterations in neuronal activity within cerebellar regions are associated with cognitive decline. |
| format | Article |
| id | doaj-art-579648b6033b40f2869b363b442e9bda |
| institution | Kabale University |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj-art-579648b6033b40f2869b363b442e9bda2025-08-20T03:53:51ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-03-011910.3389/fnins.2025.15437601543760Abnormal cerebellar activity and connectivity alterations of the cerebellar-limbic system in post-stroke cognitive impairment: a study based on resting state functional magnetic resonance imagingHaiyi Zhang0Juan Lu1Lu Zhang2Jidan Hu3Jiajun Yue4Yunhan Ma5Qi Yao6Pingping Jie7Min Fan8Min Fan9Min Fan10Jiliang Fang11Jie Zhao12Department of Magnetic Resonance Imaging, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Magnetic Resonance Imaging, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Acupuncture and Rehabilitation, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Radiology, The Second People’s Hospital of Neijiang, Southwest Medical University, Neijiang, Sichuan, ChinaDepartment of Magnetic Resonance Imaging, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Magnetic Resonance Imaging, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Magnetic Resonance Imaging, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Magnetic Resonance Imaging, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaMolecular Imaging Key Laboratory of Sichuan Province, Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Radiology, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Magnetic Resonance Imaging, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, ChinaBackgroundStroke is an important cause of cognitive impairment. Post-stroke cognitive impairment (PSCI) is a prevalent psychiatric disorder following stroke. However, the effects of PSCI on the cerebellum remain mostly unknown.MethodsA total of 31 PSCI patients and 31 patients without cognitive impairment after stroke were included in this study. The Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) were administered to all participants. Analyses of ALFF, fALFF, and ReHo were employed to investigate alterations in brain neuronal activity, while limbic connectivity analysis was utilized to reflect changes within the abnormal connections within brain regions.ResultsWe found that ALFF values were increased in Cerebelum_7b_R, Cerebelum_Crus1_L. fALFF values were increased in Vermis_3. The ReHo values were increased in Cerebelum_8_R, Cerebelum_Crus2_R, Cerebelum_Crus1_L. The functional connection between Frontal_Mid_Orb_L and Cerebelum_Crus2_R brain regions was decreased. The functional connection between Hippocampus_L and Cerebelum_Crus2_R brain regions was decreased. The functional connection between Vermis_3 and Frontal_Med_Orb_L brain regions was decreased.ConclusionThe severity of cognitive impairment may influence the extent of functional connectivity disruption between the cerebellum and the limbic system. Furthermore, atypical alterations in neuronal activity within cerebellar regions are associated with cognitive decline.https://www.frontiersin.org/articles/10.3389/fnins.2025.1543760/fullstrokemild cognitive impairmentcerebellumfunctional magnetic resonance imaginglimbic system |
| spellingShingle | Haiyi Zhang Juan Lu Lu Zhang Jidan Hu Jiajun Yue Yunhan Ma Qi Yao Pingping Jie Min Fan Min Fan Min Fan Jiliang Fang Jie Zhao Abnormal cerebellar activity and connectivity alterations of the cerebellar-limbic system in post-stroke cognitive impairment: a study based on resting state functional magnetic resonance imaging Frontiers in Neuroscience stroke mild cognitive impairment cerebellum functional magnetic resonance imaging limbic system |
| title | Abnormal cerebellar activity and connectivity alterations of the cerebellar-limbic system in post-stroke cognitive impairment: a study based on resting state functional magnetic resonance imaging |
| title_full | Abnormal cerebellar activity and connectivity alterations of the cerebellar-limbic system in post-stroke cognitive impairment: a study based on resting state functional magnetic resonance imaging |
| title_fullStr | Abnormal cerebellar activity and connectivity alterations of the cerebellar-limbic system in post-stroke cognitive impairment: a study based on resting state functional magnetic resonance imaging |
| title_full_unstemmed | Abnormal cerebellar activity and connectivity alterations of the cerebellar-limbic system in post-stroke cognitive impairment: a study based on resting state functional magnetic resonance imaging |
| title_short | Abnormal cerebellar activity and connectivity alterations of the cerebellar-limbic system in post-stroke cognitive impairment: a study based on resting state functional magnetic resonance imaging |
| title_sort | abnormal cerebellar activity and connectivity alterations of the cerebellar limbic system in post stroke cognitive impairment a study based on resting state functional magnetic resonance imaging |
| topic | stroke mild cognitive impairment cerebellum functional magnetic resonance imaging limbic system |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2025.1543760/full |
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