3D Electrospun Nanofiber-Based Scaffolds: From Preparations and Properties to Tissue Regeneration Applications
Electrospun nanofibers have been frequently used for tissue engineering due to their morphological similarities with the extracellular matrix (ECM) and tunable chemical and physical properties for regulating cell behaviors and functions. However, most of the existing electrospun nanofibers have a cl...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/8790143 |
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| author | Shanshan Han Kexin Nie Jingchao Li Qingqing Sun Xiaofeng Wang Xiaomeng Li Qian Li |
| author_facet | Shanshan Han Kexin Nie Jingchao Li Qingqing Sun Xiaofeng Wang Xiaomeng Li Qian Li |
| author_sort | Shanshan Han |
| collection | DOAJ |
| description | Electrospun nanofibers have been frequently used for tissue engineering due to their morphological similarities with the extracellular matrix (ECM) and tunable chemical and physical properties for regulating cell behaviors and functions. However, most of the existing electrospun nanofibers have a closely packed two-dimensional (2D) membrane with the intrinsic shortcomings of limited cellular infiltration, restricted nutrition diffusion, and unsatisfied thickness. Three-dimensional (3D) electrospun nanofiber-based scaffolds can provide stem cells with 3D microenvironments and biomimetic fibrous structures. Thus, they have been demonstrated to be good candidates for in vivo repair of different tissues. This review summarizes the recent developments in 3D electrospun nanofiber-based scaffolds (ENF-S) for tissue engineering. Three types of 3D ENF-S fabricated using different approaches classified into electrospun nanofiber 3D scaffolds, electrospun nanofiber/hydrogel composite 3D scaffolds, and electrospun nanofiber/porous matrix composite 3D scaffolds are discussed. New functions for these 3D ENF-S and properties, such as facilitated cell infiltration, 3D fibrous architecture, enhanced mechanical properties, and tunable degradability, meeting the requirements of tissue engineering scaffolds were discovered. The applications of 3D ENF-S in cartilage, bone, tendon, ligament, skeletal muscle, nerve, and cardiac tissue regeneration are then presented with a discussion of current challenges and future directions. Finally, we give summaries and future perspectives of 3D ENF-S in tissue engineering and clinical transformation. |
| format | Article |
| id | doaj-art-5791806d62cf4cd58af1e2aa86ec220c |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-5791806d62cf4cd58af1e2aa86ec220c2025-02-03T07:23:31ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/879014387901433D Electrospun Nanofiber-Based Scaffolds: From Preparations and Properties to Tissue Regeneration ApplicationsShanshan Han0Kexin Nie1Jingchao Li2Qingqing Sun3Xiaofeng Wang4Xiaomeng Li5Qian Li6School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou 450001, ChinaSchool of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou 450001, ChinaSchool of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457, SingaporeCenter for Functional Sensor and Actuator, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, JapanSchool of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou 450001, ChinaSchool of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou 450001, ChinaSchool of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou 450001, ChinaElectrospun nanofibers have been frequently used for tissue engineering due to their morphological similarities with the extracellular matrix (ECM) and tunable chemical and physical properties for regulating cell behaviors and functions. However, most of the existing electrospun nanofibers have a closely packed two-dimensional (2D) membrane with the intrinsic shortcomings of limited cellular infiltration, restricted nutrition diffusion, and unsatisfied thickness. Three-dimensional (3D) electrospun nanofiber-based scaffolds can provide stem cells with 3D microenvironments and biomimetic fibrous structures. Thus, they have been demonstrated to be good candidates for in vivo repair of different tissues. This review summarizes the recent developments in 3D electrospun nanofiber-based scaffolds (ENF-S) for tissue engineering. Three types of 3D ENF-S fabricated using different approaches classified into electrospun nanofiber 3D scaffolds, electrospun nanofiber/hydrogel composite 3D scaffolds, and electrospun nanofiber/porous matrix composite 3D scaffolds are discussed. New functions for these 3D ENF-S and properties, such as facilitated cell infiltration, 3D fibrous architecture, enhanced mechanical properties, and tunable degradability, meeting the requirements of tissue engineering scaffolds were discovered. The applications of 3D ENF-S in cartilage, bone, tendon, ligament, skeletal muscle, nerve, and cardiac tissue regeneration are then presented with a discussion of current challenges and future directions. Finally, we give summaries and future perspectives of 3D ENF-S in tissue engineering and clinical transformation.http://dx.doi.org/10.1155/2021/8790143 |
| spellingShingle | Shanshan Han Kexin Nie Jingchao Li Qingqing Sun Xiaofeng Wang Xiaomeng Li Qian Li 3D Electrospun Nanofiber-Based Scaffolds: From Preparations and Properties to Tissue Regeneration Applications Stem Cells International |
| title | 3D Electrospun Nanofiber-Based Scaffolds: From Preparations and Properties to Tissue Regeneration Applications |
| title_full | 3D Electrospun Nanofiber-Based Scaffolds: From Preparations and Properties to Tissue Regeneration Applications |
| title_fullStr | 3D Electrospun Nanofiber-Based Scaffolds: From Preparations and Properties to Tissue Regeneration Applications |
| title_full_unstemmed | 3D Electrospun Nanofiber-Based Scaffolds: From Preparations and Properties to Tissue Regeneration Applications |
| title_short | 3D Electrospun Nanofiber-Based Scaffolds: From Preparations and Properties to Tissue Regeneration Applications |
| title_sort | 3d electrospun nanofiber based scaffolds from preparations and properties to tissue regeneration applications |
| url | http://dx.doi.org/10.1155/2021/8790143 |
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