Military Service Roles and ALS Among Veterans: A Matched Case–Control Study
ABSTRACT While military service is an established risk factor for amyotrophic lateral sclerosis (ALS), it remains unclear whether this association is linked to combat. We conducted a matched case–control study comparing 191 ALS patients who were veterans of the Israeli Defense Forces (IDF) with know...
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | Annals of Clinical and Translational Neurology |
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| Online Access: | https://doi.org/10.1002/acn3.70079 |
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| author | Asaf Honig Roy Dayan Amir Knaani Hagai Levine Marc Gotkine |
| author_facet | Asaf Honig Roy Dayan Amir Knaani Hagai Levine Marc Gotkine |
| author_sort | Asaf Honig |
| collection | DOAJ |
| description | ABSTRACT While military service is an established risk factor for amyotrophic lateral sclerosis (ALS), it remains unclear whether this association is linked to combat. We conducted a matched case–control study comparing 191 ALS patients who were veterans of the Israeli Defense Forces (IDF) with known military service type and 1910 matched controls. The ALS group had higher rates of combat service (46.0% vs. 22.7%) and parachuting (10.5% vs. 1.1%) in comparison with controls (p < 0.001 for both). In a multivariate model, combat service was associated with ALS (odds ratio 2.49, confidence interval [1.49–4.16], p < 0.01). The higher prevalence of combat roles among ALS patients expands our understanding of military service factors that contribute to ALS risk. |
| format | Article |
| id | doaj-art-5786b69f0eca42e7a48059888ee5dac4 |
| institution | DOAJ |
| issn | 2328-9503 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj-art-5786b69f0eca42e7a48059888ee5dac42025-08-20T03:02:44ZengWileyAnnals of Clinical and Translational Neurology2328-95032025-08-011281702170510.1002/acn3.70079Military Service Roles and ALS Among Veterans: A Matched Case–Control StudyAsaf Honig0Roy Dayan1Amir Knaani2Hagai Levine3Marc Gotkine4Department of Neurology Soroka Medical Center Beer‐Sheva IsraelDepartment of Neurology Faculty of Medicine, Hadassah Medical Organization, Hebrew University of Jerusalem Jerusalem IsraelGeha Mental Health Center Petach‐Tikva IsraelFaculty of Medicine, Braun School of Public Health, Hadassah Medical Organization Hebrew University of Jerusalem Jerusalem IsraelDepartment of Neurology Faculty of Medicine, Hadassah Medical Organization, Hebrew University of Jerusalem Jerusalem IsraelABSTRACT While military service is an established risk factor for amyotrophic lateral sclerosis (ALS), it remains unclear whether this association is linked to combat. We conducted a matched case–control study comparing 191 ALS patients who were veterans of the Israeli Defense Forces (IDF) with known military service type and 1910 matched controls. The ALS group had higher rates of combat service (46.0% vs. 22.7%) and parachuting (10.5% vs. 1.1%) in comparison with controls (p < 0.001 for both). In a multivariate model, combat service was associated with ALS (odds ratio 2.49, confidence interval [1.49–4.16], p < 0.01). The higher prevalence of combat roles among ALS patients expands our understanding of military service factors that contribute to ALS risk.https://doi.org/10.1002/acn3.70079amyotrophic lateral sclerosis (ALS)exercisemilitary servicemotor neuron disease (MND)veterans |
| spellingShingle | Asaf Honig Roy Dayan Amir Knaani Hagai Levine Marc Gotkine Military Service Roles and ALS Among Veterans: A Matched Case–Control Study Annals of Clinical and Translational Neurology amyotrophic lateral sclerosis (ALS) exercise military service motor neuron disease (MND) veterans |
| title | Military Service Roles and ALS Among Veterans: A Matched Case–Control Study |
| title_full | Military Service Roles and ALS Among Veterans: A Matched Case–Control Study |
| title_fullStr | Military Service Roles and ALS Among Veterans: A Matched Case–Control Study |
| title_full_unstemmed | Military Service Roles and ALS Among Veterans: A Matched Case–Control Study |
| title_short | Military Service Roles and ALS Among Veterans: A Matched Case–Control Study |
| title_sort | military service roles and als among veterans a matched case control study |
| topic | amyotrophic lateral sclerosis (ALS) exercise military service motor neuron disease (MND) veterans |
| url | https://doi.org/10.1002/acn3.70079 |
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