Expression Significance and Prognostic Value of GPR27 in Ovarian Cancer
Background This study explored the prognostic role of GPR27 and its predictive value to platinum-based therapy in ovarian cancer.Material and methods A survival analysis of GPR27, and the therapeutic response to platinum in ovarian cancer was investigated using data from the cancer genome atlas (TCG...
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Taylor & Francis Group
2025-12-01
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| Series: | Journal of Investigative Surgery |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/08941939.2025.2491781 |
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| author | Xiulan Peng Yahong Cai Bing Tang Mingtao Zhang Xia Wang |
| author_facet | Xiulan Peng Yahong Cai Bing Tang Mingtao Zhang Xia Wang |
| author_sort | Xiulan Peng |
| collection | DOAJ |
| description | Background This study explored the prognostic role of GPR27 and its predictive value to platinum-based therapy in ovarian cancer.Material and methods A survival analysis of GPR27, and the therapeutic response to platinum in ovarian cancer was investigated using data from the cancer genome atlas (TCGA) and Gene Expression Omnibus (GEO) databases. GPR27 expression was assessed using reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry.Results Database analysis and RT-PCR revealed over-expression of GPR27 mRNA in ovarian cancer tissues compared to normal ovarian tissues. Ovarian cancer patients with up-regulated GPR27 transcription were associated with better overall survival and disease-free survival compared to those with downregulated GPR27 mRNA in the TCGA dataset and Kaplan-Meier plot database (N = 1656). GPR27 demonstrated good predictive value for pathological response in patients with ovarian cancer receiving platinum-based therapy. The predictive performance for 6-month relapse-free survival was higher in endometrioid ovarian cancer (AUC:0.804) than that in serous ovarian cancer. GPR27 protein levels were significantly up-regulated in ovarian cancer tissues compared with normal ovarian tissue, and high GPR27 protein expression correlated with early-stage TNM. ROC analysis revealed that the GPR27 protein, quantified by the immunohistochemistry score, effectively predicted the response to platinum-based therapy response with an AUC of 0.7479 in our cohort.Conclusion GPR27 was up-regulated in ovarian cancer, compared with that of normal ovarian tissue, and was strongly correlated with survival outcomes and response to platinum-based therapy. GPR27 may serve as a reliable biomarker for platinum -based therapy in ovarian cancer patients. |
| format | Article |
| id | doaj-art-5782f6b76a4a4be1a6f7dd4b692367bf |
| institution | OA Journals |
| issn | 0894-1939 1521-0553 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj-art-5782f6b76a4a4be1a6f7dd4b692367bf2025-08-20T02:24:35ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532025-12-0138110.1080/08941939.2025.2491781Expression Significance and Prognostic Value of GPR27 in Ovarian CancerXiulan Peng0Yahong Cai1Bing Tang2Mingtao Zhang3Xia Wang4Department of Oncology, The Second Affiliated Hospital of Jianghan University, Wuhan, Hubei Province, ChinaDepartment of Oncology, The Second Affiliated Hospital of Jianghan University, Wuhan, Hubei Province, ChinaDepartment of orthopedics, The People Hospital of Yunmeng, Xiaogan, Hubei Province, ChinaDepartment of Radiation Oncology, Jing men NO.1 People’s Hospital, Jingmen, Hubei, ChinaDepartment of Pharmacy, The Second Affiliated Hospital of Jianghan University, Wuhan, Hubei Province, ChinaBackground This study explored the prognostic role of GPR27 and its predictive value to platinum-based therapy in ovarian cancer.Material and methods A survival analysis of GPR27, and the therapeutic response to platinum in ovarian cancer was investigated using data from the cancer genome atlas (TCGA) and Gene Expression Omnibus (GEO) databases. GPR27 expression was assessed using reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry.Results Database analysis and RT-PCR revealed over-expression of GPR27 mRNA in ovarian cancer tissues compared to normal ovarian tissues. Ovarian cancer patients with up-regulated GPR27 transcription were associated with better overall survival and disease-free survival compared to those with downregulated GPR27 mRNA in the TCGA dataset and Kaplan-Meier plot database (N = 1656). GPR27 demonstrated good predictive value for pathological response in patients with ovarian cancer receiving platinum-based therapy. The predictive performance for 6-month relapse-free survival was higher in endometrioid ovarian cancer (AUC:0.804) than that in serous ovarian cancer. GPR27 protein levels were significantly up-regulated in ovarian cancer tissues compared with normal ovarian tissue, and high GPR27 protein expression correlated with early-stage TNM. ROC analysis revealed that the GPR27 protein, quantified by the immunohistochemistry score, effectively predicted the response to platinum-based therapy response with an AUC of 0.7479 in our cohort.Conclusion GPR27 was up-regulated in ovarian cancer, compared with that of normal ovarian tissue, and was strongly correlated with survival outcomes and response to platinum-based therapy. GPR27 may serve as a reliable biomarker for platinum -based therapy in ovarian cancer patients.https://www.tandfonline.com/doi/10.1080/08941939.2025.2491781G protein-coupled receptorsovarian cancerplatinumtreatment responsepredictive biomarker |
| spellingShingle | Xiulan Peng Yahong Cai Bing Tang Mingtao Zhang Xia Wang Expression Significance and Prognostic Value of GPR27 in Ovarian Cancer Journal of Investigative Surgery G protein-coupled receptors ovarian cancer platinum treatment response predictive biomarker |
| title | Expression Significance and Prognostic Value of GPR27 in Ovarian Cancer |
| title_full | Expression Significance and Prognostic Value of GPR27 in Ovarian Cancer |
| title_fullStr | Expression Significance and Prognostic Value of GPR27 in Ovarian Cancer |
| title_full_unstemmed | Expression Significance and Prognostic Value of GPR27 in Ovarian Cancer |
| title_short | Expression Significance and Prognostic Value of GPR27 in Ovarian Cancer |
| title_sort | expression significance and prognostic value of gpr27 in ovarian cancer |
| topic | G protein-coupled receptors ovarian cancer platinum treatment response predictive biomarker |
| url | https://www.tandfonline.com/doi/10.1080/08941939.2025.2491781 |
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