Two Case Presentations Infected by Trichosporon asahii and Treated with Voriconazole Successfully
Background. Trichosporon asahii is an opportunistic fungus that causes infections in immunosuppressed patients. Neutropenia developing due to malignancies is an important risk factor for fungal infection. Case Report. We present two pediatric oncology cases successfully treated with voriconazole aft...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2015/651315 |
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| author | Hikmet Gulsah Tanyildiz Sule Yesil Sule Toprak Mehmet Onur Candir Gurses Sahin |
| author_facet | Hikmet Gulsah Tanyildiz Sule Yesil Sule Toprak Mehmet Onur Candir Gurses Sahin |
| author_sort | Hikmet Gulsah Tanyildiz |
| collection | DOAJ |
| description | Background. Trichosporon asahii is an opportunistic fungus that causes infections in immunosuppressed patients. Neutropenia developing due to malignancies is an important risk factor for fungal infection. Case Report. We present two pediatric oncology cases successfully treated with voriconazole after T. asahii infection that is known to cause fatal sepsis and invasive fungal infection. Conclusion. There is no conclusive evidence that the antifungal agent voriconazole is effective in the neutropenic patients infected with Trichosporon asahii. Liposomal amphotericin B has also been reported to be inadequate for treatment. We believe that our patients were successfully treated and survived because the antifungal agents were started early and properly, although the infection can be fatal in up to 80% of cases despite treatment. |
| format | Article |
| id | doaj-art-577facdb51044d2eaaaa96f3e7c95ca6 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-577facdb51044d2eaaaa96f3e7c95ca62025-02-03T06:42:19ZengWileyCase Reports in Infectious Diseases2090-66252090-66332015-01-01201510.1155/2015/651315651315Two Case Presentations Infected by Trichosporon asahii and Treated with Voriconazole SuccessfullyHikmet Gulsah Tanyildiz0Sule Yesil1Sule Toprak2Mehmet Onur Candir3Gurses Sahin4Dr. Sami Ulus Maternity and Children’s Health and Diseases Training and Research Hospital, Department of Pediatric Oncology and Haematology, Ankara, TurkeyDr. Sami Ulus Maternity and Children’s Health and Diseases Training and Research Hospital, Department of Pediatric Oncology and Haematology, Ankara, TurkeyDr. Sami Ulus Maternity and Children’s Health and Diseases Training and Research Hospital, Department of Pediatric Oncology and Haematology, Ankara, TurkeyDr. Sami Ulus Maternity and Children’s Health and Diseases Training and Research Hospital, Department of Pediatric Oncology and Haematology, Ankara, TurkeyDr. Sami Ulus Maternity and Children’s Health and Diseases Training and Research Hospital, Department of Pediatric Oncology and Haematology, Ankara, TurkeyBackground. Trichosporon asahii is an opportunistic fungus that causes infections in immunosuppressed patients. Neutropenia developing due to malignancies is an important risk factor for fungal infection. Case Report. We present two pediatric oncology cases successfully treated with voriconazole after T. asahii infection that is known to cause fatal sepsis and invasive fungal infection. Conclusion. There is no conclusive evidence that the antifungal agent voriconazole is effective in the neutropenic patients infected with Trichosporon asahii. Liposomal amphotericin B has also been reported to be inadequate for treatment. We believe that our patients were successfully treated and survived because the antifungal agents were started early and properly, although the infection can be fatal in up to 80% of cases despite treatment.http://dx.doi.org/10.1155/2015/651315 |
| spellingShingle | Hikmet Gulsah Tanyildiz Sule Yesil Sule Toprak Mehmet Onur Candir Gurses Sahin Two Case Presentations Infected by Trichosporon asahii and Treated with Voriconazole Successfully Case Reports in Infectious Diseases |
| title | Two Case Presentations Infected by Trichosporon asahii and Treated with Voriconazole Successfully |
| title_full | Two Case Presentations Infected by Trichosporon asahii and Treated with Voriconazole Successfully |
| title_fullStr | Two Case Presentations Infected by Trichosporon asahii and Treated with Voriconazole Successfully |
| title_full_unstemmed | Two Case Presentations Infected by Trichosporon asahii and Treated with Voriconazole Successfully |
| title_short | Two Case Presentations Infected by Trichosporon asahii and Treated with Voriconazole Successfully |
| title_sort | two case presentations infected by trichosporon asahii and treated with voriconazole successfully |
| url | http://dx.doi.org/10.1155/2015/651315 |
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