Kinetics Investigation on Mushroom Tyrosinase Inhibition of Proso Millet
Proso millet (Panicum miliaceum) is rich in nutritive components and is widely used as a human food, feed and forage for animals, and fuel. This study investigated the effect of a proso millet extract on the inhibition of tyrosinase, a key enzyme in melanogenesis. High performance liquid chromatogra...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2018/2387926 |
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| author | Wen-Ying Huang Hui-Ju Chen Chia-Ching Lin Chin-Shuh Chen Yung-Sheng Lin |
| author_facet | Wen-Ying Huang Hui-Ju Chen Chia-Ching Lin Chin-Shuh Chen Yung-Sheng Lin |
| author_sort | Wen-Ying Huang |
| collection | DOAJ |
| description | Proso millet (Panicum miliaceum) is rich in nutritive components and is widely used as a human food, feed and forage for animals, and fuel. This study investigated the effect of a proso millet extract on the inhibition of tyrosinase, a key enzyme in melanogenesis. High performance liquid chromatography analysis indicated that the proso millet extract contained phenolic tyrosinase inhibitors, such as syringic acid, p-coumaric acid, and ferulic acid. The extract had an IC50 for inhibition of tyrosinase activity of 14.02 mg/mL. A Lineweaver-Burk double reciprocal plot showed that the proso millet extract functioned as a mixed competitive and noncompetitive inhibitor. Proso millet has potential as a tyrosinase inhibitor that may have applications in the cosmetics industry. |
| format | Article |
| id | doaj-art-577dcbdd53bf40019587b7fc6834dba3 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-577dcbdd53bf40019587b7fc6834dba32025-08-20T03:33:36ZengWileyJournal of Chemistry2090-90632090-90712018-01-01201810.1155/2018/23879262387926Kinetics Investigation on Mushroom Tyrosinase Inhibition of Proso MilletWen-Ying Huang0Hui-Ju Chen1Chia-Ching Lin2Chin-Shuh Chen3Yung-Sheng Lin4Department of Applied Cosmetology, Hung-Kuang University, Taichung, TaiwanDepartment of Food Science and Biotechnology, National Chung Hsing University, Taichung, TaiwanDepartment of Applied Cosmetology, Hung-Kuang University, Taichung, TaiwanDepartment of Food Science and Biotechnology, National Chung Hsing University, Taichung, TaiwanDepartment of Chemical Engineering, National United University, Miaoli City, TaiwanProso millet (Panicum miliaceum) is rich in nutritive components and is widely used as a human food, feed and forage for animals, and fuel. This study investigated the effect of a proso millet extract on the inhibition of tyrosinase, a key enzyme in melanogenesis. High performance liquid chromatography analysis indicated that the proso millet extract contained phenolic tyrosinase inhibitors, such as syringic acid, p-coumaric acid, and ferulic acid. The extract had an IC50 for inhibition of tyrosinase activity of 14.02 mg/mL. A Lineweaver-Burk double reciprocal plot showed that the proso millet extract functioned as a mixed competitive and noncompetitive inhibitor. Proso millet has potential as a tyrosinase inhibitor that may have applications in the cosmetics industry.http://dx.doi.org/10.1155/2018/2387926 |
| spellingShingle | Wen-Ying Huang Hui-Ju Chen Chia-Ching Lin Chin-Shuh Chen Yung-Sheng Lin Kinetics Investigation on Mushroom Tyrosinase Inhibition of Proso Millet Journal of Chemistry |
| title | Kinetics Investigation on Mushroom Tyrosinase Inhibition of Proso Millet |
| title_full | Kinetics Investigation on Mushroom Tyrosinase Inhibition of Proso Millet |
| title_fullStr | Kinetics Investigation on Mushroom Tyrosinase Inhibition of Proso Millet |
| title_full_unstemmed | Kinetics Investigation on Mushroom Tyrosinase Inhibition of Proso Millet |
| title_short | Kinetics Investigation on Mushroom Tyrosinase Inhibition of Proso Millet |
| title_sort | kinetics investigation on mushroom tyrosinase inhibition of proso millet |
| url | http://dx.doi.org/10.1155/2018/2387926 |
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