Biomedical applications of organoids in genetic diseases
Organoid technology has significantly transformed biomedical research by providing exceptional prospects for modeling human tissues and disorders in a laboratory setting. It has significant potential for understanding the intricate relationship between genetic mutations, cellular phenotypes, and dis...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2025-04-01
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| Series: | Medical Review |
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| Online Access: | https://doi.org/10.1515/mr-2024-0077 |
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| _version_ | 1849738421627518976 |
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| author | Huang Wenhua Jeong Seogsong Kim Won Chen Lei |
| author_facet | Huang Wenhua Jeong Seogsong Kim Won Chen Lei |
| author_sort | Huang Wenhua |
| collection | DOAJ |
| description | Organoid technology has significantly transformed biomedical research by providing exceptional prospects for modeling human tissues and disorders in a laboratory setting. It has significant potential for understanding the intricate relationship between genetic mutations, cellular phenotypes, and disease pathology, especially in the field of genetic diseases. The intersection of organoid technology and genetic research offers great promise for comprehending the pathophysiology of genetic diseases and creating innovative treatment approaches customized for specific patients. This review aimed to present a thorough analysis of the current advancements in organoid technology and its biomedical applications for genetic diseases. We examined techniques for modeling genetic disorders using organoid platforms, analyze the approaches for incorporating genetic disease organoids into clinical practice, and showcase current breakthroughs in preclinical application, individualized healthcare, and transplantation. Through the integration of knowledge from several disciplines, such as genetics, regenerative medicine, and biological engineering, our aim is to enhance our comprehension of the complex connection between genetic variations and organoid models in relation to human health and disease. |
| format | Article |
| id | doaj-art-577d842881ed42be8b2cddd7af3ddbc5 |
| institution | DOAJ |
| issn | 2749-9642 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Medical Review |
| spelling | doaj-art-577d842881ed42be8b2cddd7af3ddbc52025-08-20T03:06:36ZengDe GruyterMedical Review2749-96422025-04-015215216310.1515/mr-2024-0077Biomedical applications of organoids in genetic diseasesHuang Wenhua0Jeong Seogsong1Kim Won2Chen Lei312521International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital/National Center for Liver Cancer, Naval Medical University, Shanghai, ChinaDepartment of Biomedical Informatics, Korea University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea12521International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital/National Center for Liver Cancer, Naval Medical University, Shanghai, ChinaOrganoid technology has significantly transformed biomedical research by providing exceptional prospects for modeling human tissues and disorders in a laboratory setting. It has significant potential for understanding the intricate relationship between genetic mutations, cellular phenotypes, and disease pathology, especially in the field of genetic diseases. The intersection of organoid technology and genetic research offers great promise for comprehending the pathophysiology of genetic diseases and creating innovative treatment approaches customized for specific patients. This review aimed to present a thorough analysis of the current advancements in organoid technology and its biomedical applications for genetic diseases. We examined techniques for modeling genetic disorders using organoid platforms, analyze the approaches for incorporating genetic disease organoids into clinical practice, and showcase current breakthroughs in preclinical application, individualized healthcare, and transplantation. Through the integration of knowledge from several disciplines, such as genetics, regenerative medicine, and biological engineering, our aim is to enhance our comprehension of the complex connection between genetic variations and organoid models in relation to human health and disease.https://doi.org/10.1515/mr-2024-0077organoid modelsdiagnosis and prognosispreclinical researchdrug discoverytransplantation |
| spellingShingle | Huang Wenhua Jeong Seogsong Kim Won Chen Lei Biomedical applications of organoids in genetic diseases Medical Review organoid models diagnosis and prognosis preclinical research drug discovery transplantation |
| title | Biomedical applications of organoids in genetic diseases |
| title_full | Biomedical applications of organoids in genetic diseases |
| title_fullStr | Biomedical applications of organoids in genetic diseases |
| title_full_unstemmed | Biomedical applications of organoids in genetic diseases |
| title_short | Biomedical applications of organoids in genetic diseases |
| title_sort | biomedical applications of organoids in genetic diseases |
| topic | organoid models diagnosis and prognosis preclinical research drug discovery transplantation |
| url | https://doi.org/10.1515/mr-2024-0077 |
| work_keys_str_mv | AT huangwenhua biomedicalapplicationsoforganoidsingeneticdiseases AT jeongseogsong biomedicalapplicationsoforganoidsingeneticdiseases AT kimwon biomedicalapplicationsoforganoidsingeneticdiseases AT chenlei biomedicalapplicationsoforganoidsingeneticdiseases |