Serum creatinine to cystatin C ratio as monitoring biomarker in Chinese adult spinal muscular atrophy: a prospective cohort study

Serum creatinine to cystatin C ratio as monitoring biomarker in Chinese adult spinal muscular atrophy: a prospective cohort study

Abstract Background The creatinine to cystatin C ratio (CCR) can be used as a biomarker of muscle mass and strength, but no studies have evaluated whether it can be used as a biomarker to monitor the efficacy of treatment with nusinersen in Chinese adults with 5q-associated spinal muscular atrophy (...

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Bibliographic Details
Main Authors: Sihui Chen, Qiong Wang, Jiajia Fu, Qianqian Wei, Ruwei Ou, Xiaohui Lai, Xueping Chen, Huifang Shang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Orphanet Journal of Rare Diseases
Subjects:
Spinal muscular atrophy
Serum biomarkers
Nusinersen
Correlation analysis
Online Access:https://doi.org/10.1186/s13023-025-03730-3
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