Switch to mania after acute antidepressant treatment for bipolar depression: a systematic review and network meta-analysis of randomised controlled trialsResearch in context

Switch to mania after acute antidepressant treatment for bipolar depression: a systematic review and network meta-analysis of randomised controlled trialsResearch in context

Summary: Background: The potential for antidepressants to induce a switch to mania remains a major concern in the treatment of bipolar depression, but the specific risk associated with different antidepressants remains unclear. This systematic review and network meta-analysis (NMA) assessed this ri...

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Main Authors: Vincenzo Oliva, Michele De Prisco, Enrico La Spina, Sofia Paolucci, Giovanna Fico, Gerard Anmella, Diego Hidalgo-Mazzei, Andrea Murru, Maurizio Pompili, Michele Fornaro, Marco Solmi, Ayşegül Yildiz, Stefan Leucht, Eduard Vieta, Joaquim Radua
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:EClinicalMedicine
Subjects:
Bipolar disorder
Bipolar depression
Switch to mania
Antidepressant treatment
Network meta-analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537025003451
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