Extracellular matrix remodeling fibroblasts govern the tumor microenvironment disparity between adenomatous lesions and adenocarcinoma in gallbladder

IntroductionGallbladder cancer (GBC) is a highly lethal cancer with a poor prognosis. The adenoma-carcinoma sequence is a recognized model for GBC development, but its underlying mechanisms are not well understood. MethodsHuman specimens were collected from Shengjing Hospital of China Medical Univer...

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Bibliographic Details
Main Authors: Chuhan Ma, Huixin Hu, Hanrong Li, Bing Han, Chao Lv, Yu Tian
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
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Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1637300/full
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