Targeting microRNA-dependent control of X chromosome inactivation improves the Rett Syndrome phenotype

Targeting microRNA-dependent control of X chromosome inactivation improves the Rett Syndrome phenotype

Abstract X chromosome inactivation (XCI) is induced by Xist long non-coding RNA and protein-coding genes. However, the role of small non-coding RNA function in XCI remains unidentified. Our genome-wide, loss-of-function CRISPR/Cas9 screen in female fibroblasts identified microRNAs (miRNAs) as regula...

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Main Authors: Song Lou, Rachisan DJiake Tihagam, Urszula N. Wasko, Zaffar Equbal, Sanjay Venkatesan, Klaudia Braczyk, Piotr Przanowski, Bon Il Koo, Ilyas Saltani, Arjun Tushir Singh, Shibi Likhite, Samantha Powers, George M. P. R. Souza, Robert A. Maxwell, Jun Yu, Lihua J. Zhu, Mark Beenhakker, Stephen B. G. Abbott, Zhipeng Lu, Michael R. Green, Kathrin C. Meyer, Jogender Tushir-Singh, Sanchita Bhatnagar
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61092-7
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