α-Calcium sulphate hemihydrate with high aspect ratio crystalline as porous-structured biodegradable ceramic for bone regeneration
Porous-structured bioceramics have emerged as an advanced approach in bone regeneration due to several advantages, including improved nutrient and oxygen diffusion, accessible space for cell attachment and proliferation, superior mechanical compatibility with surrounding tissues, and enhanced bone...
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| Format: | Article |
| Language: | English |
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Vietnam Ministry of Science and Technology
2025-06-01
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| Series: | Vietnam Journal of Science, Technology and Engineering |
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| Online Access: | https://vietnamscience.vjst.vn/index.php/vjste/article/view/1277 |
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| author | Anh Phuong Nguyen Hong Dieu Linh Tran Ngoc Thuy Trang Le Quoc Vinh Ho Minh Hoang Vo Do Dang Khoa Vo Nguyen Van Du Cao Dai Hai Nguyen |
| author_facet | Anh Phuong Nguyen Hong Dieu Linh Tran Ngoc Thuy Trang Le Quoc Vinh Ho Minh Hoang Vo Do Dang Khoa Vo Nguyen Van Du Cao Dai Hai Nguyen |
| author_sort | Anh Phuong Nguyen Hong |
| collection | DOAJ |
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Porous-structured bioceramics have emerged as an advanced approach in bone regeneration due to several advantages, including improved nutrient and oxygen diffusion, accessible space for cell attachment and proliferation, superior mechanical compatibility with surrounding tissues, and enhanced bone healing. Therefore, in this study, porous alpha- calcium sulphate hemihydrate (α-HH) was synthesised via a one-step salt solution method using calcium chloride. A key advantage of using calcium chloride in this method is that it not only improves the purity of the product but also promotes the formation of high-aspect-ratio α-HH crystals, thereby facilitating the development of a porous structure more effectively. The prepared porous α-HH was characterised using several modern analytical techniques, including Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and field emission scanning electron microscopy (FE-SEM). These analyses revealed that the synthesised powder met medical-grade standards and exhibited a porosity of 61.32%±3.2, with a compressive strength of 5.04±0.11 MPa. In vitro tests further demonstrated the material’s commendable biodegradability, as well as its capacity for mineralisation, cell adhesion, and migration, suggesting that porous α-HH is a promising biomaterial for bone engineering.
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| format | Article |
| id | doaj-art-57651873788c4f26a121fd92c5205dbe |
| institution | OA Journals |
| issn | 2525-2461 2615-9937 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Vietnam Ministry of Science and Technology |
| record_format | Article |
| series | Vietnam Journal of Science, Technology and Engineering |
| spelling | doaj-art-57651873788c4f26a121fd92c5205dbe2025-08-20T02:07:01ZengVietnam Ministry of Science and TechnologyVietnam Journal of Science, Technology and Engineering2525-24612615-99372025-06-01672α-Calcium sulphate hemihydrate with high aspect ratio crystalline as porous-structured biodegradable ceramic for bone regenerationAnh Phuong Nguyen HongDieu Linh TranNgoc Thuy Trang LeQuoc Vinh HoMinh Hoang Vo DoDang Khoa Vo NguyenVan Du CaoDai Hai Nguyen Porous-structured bioceramics have emerged as an advanced approach in bone regeneration due to several advantages, including improved nutrient and oxygen diffusion, accessible space for cell attachment and proliferation, superior mechanical compatibility with surrounding tissues, and enhanced bone healing. Therefore, in this study, porous alpha- calcium sulphate hemihydrate (α-HH) was synthesised via a one-step salt solution method using calcium chloride. A key advantage of using calcium chloride in this method is that it not only improves the purity of the product but also promotes the formation of high-aspect-ratio α-HH crystals, thereby facilitating the development of a porous structure more effectively. The prepared porous α-HH was characterised using several modern analytical techniques, including Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and field emission scanning electron microscopy (FE-SEM). These analyses revealed that the synthesised powder met medical-grade standards and exhibited a porosity of 61.32%±3.2, with a compressive strength of 5.04±0.11 MPa. In vitro tests further demonstrated the material’s commendable biodegradability, as well as its capacity for mineralisation, cell adhesion, and migration, suggesting that porous α-HH is a promising biomaterial for bone engineering. https://vietnamscience.vjst.vn/index.php/vjste/article/view/1277biodegradable ceramicbone regenerationcalcium sulphate hemihydrateporous structure |
| spellingShingle | Anh Phuong Nguyen Hong Dieu Linh Tran Ngoc Thuy Trang Le Quoc Vinh Ho Minh Hoang Vo Do Dang Khoa Vo Nguyen Van Du Cao Dai Hai Nguyen α-Calcium sulphate hemihydrate with high aspect ratio crystalline as porous-structured biodegradable ceramic for bone regeneration Vietnam Journal of Science, Technology and Engineering biodegradable ceramic bone regeneration calcium sulphate hemihydrate porous structure |
| title | α-Calcium sulphate hemihydrate with high aspect ratio crystalline as porous-structured biodegradable ceramic for bone regeneration |
| title_full | α-Calcium sulphate hemihydrate with high aspect ratio crystalline as porous-structured biodegradable ceramic for bone regeneration |
| title_fullStr | α-Calcium sulphate hemihydrate with high aspect ratio crystalline as porous-structured biodegradable ceramic for bone regeneration |
| title_full_unstemmed | α-Calcium sulphate hemihydrate with high aspect ratio crystalline as porous-structured biodegradable ceramic for bone regeneration |
| title_short | α-Calcium sulphate hemihydrate with high aspect ratio crystalline as porous-structured biodegradable ceramic for bone regeneration |
| title_sort | α calcium sulphate hemihydrate with high aspect ratio crystalline as porous structured biodegradable ceramic for bone regeneration |
| topic | biodegradable ceramic bone regeneration calcium sulphate hemihydrate porous structure |
| url | https://vietnamscience.vjst.vn/index.php/vjste/article/view/1277 |
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