Exercise-diet intervention ameliorates but fails to fully reverse obesity-induced ovarian dysfunction: evidence spanning folliculogenesis to embryonic development

Exercise-diet intervention ameliorates but fails to fully reverse obesity-induced ovarian dysfunction: evidence spanning folliculogenesis to embryonic development

Abstract Obesity, a globally prevalent chronic disease, disrupts systemic homeostasis and impairs female fertility, yet the mechanisms linking adipose dysfunction to ovarian reserve remain unclear. Using high-fat diet-induced obese C57BL/6 mouse models (HFD) and exercise-diet intervention models (SE...

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Bibliographic Details
Main Authors:	Chen Xinyan, Yu Ting, Zhang Xi, He Shangfan, Li Junwei, Zhu jiaqiao, Ju Huiming, Li Feng, Xue Tongmin
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Series:	Journal of Ovarian Research
Online Access:	https://doi.org/10.1186/s13048-025-01748-6
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