Synthesis and Characterization of Process-Related Impurities of Antihypertensive Drug Olmesartan Medoxomil
Olmesartan medoxomil (1) is the latest angiotensin receptor antagonist approved by the FDA for the treatment of hypertension. During the process development of olmesartan medoxomil, three process-related impurities were observed along with the final API. These impurities were identified as isopropyl...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/516459 |
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| author | G. Venkanna G. Madhusudhan K. Mukkanti A. Sankar Y. Sampath Kumar G. Venakata Narayana |
| author_facet | G. Venkanna G. Madhusudhan K. Mukkanti A. Sankar Y. Sampath Kumar G. Venakata Narayana |
| author_sort | G. Venkanna |
| collection | DOAJ |
| description | Olmesartan medoxomil (1) is the latest angiotensin receptor antagonist approved by the FDA for the treatment of hypertension. During the process development of olmesartan medoxomil, three process-related impurities were observed along with the final API. These impurities were identified as isopropyl olmesartan (12), dimedoxomil olmesartan (19), dibiphenyl olmesartan (17). The present work describes the synthesis and characterization of all these three impurities. |
| format | Article |
| id | doaj-art-575f440314574449b4b2c8fa373a08ea |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-575f440314574449b4b2c8fa373a08ea2025-02-03T06:48:28ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/516459516459Synthesis and Characterization of Process-Related Impurities of Antihypertensive Drug Olmesartan MedoxomilG. Venkanna0G. Madhusudhan1K. Mukkanti2A. Sankar3Y. Sampath Kumar4G. Venakata Narayana5Department of Research and Development, Inogent Laboratories Private Limited, 28A, IDA, Nacharam, Hyderabad 500 076, IndiaDepartment of Research and Development, Inogent Laboratories Private Limited, 28A, IDA, Nacharam, Hyderabad 500 076, IndiaCentre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad 500 072, IndiaDepartment of Research and Development, Inogent Laboratories Private Limited, 28A, IDA, Nacharam, Hyderabad 500 076, IndiaDepartment of Research and Development, Inogent Laboratories Private Limited, 28A, IDA, Nacharam, Hyderabad 500 076, IndiaDepartment of Research and Development, Inogent Laboratories Private Limited, 28A, IDA, Nacharam, Hyderabad 500 076, IndiaOlmesartan medoxomil (1) is the latest angiotensin receptor antagonist approved by the FDA for the treatment of hypertension. During the process development of olmesartan medoxomil, three process-related impurities were observed along with the final API. These impurities were identified as isopropyl olmesartan (12), dimedoxomil olmesartan (19), dibiphenyl olmesartan (17). The present work describes the synthesis and characterization of all these three impurities.http://dx.doi.org/10.1155/2013/516459 |
| spellingShingle | G. Venkanna G. Madhusudhan K. Mukkanti A. Sankar Y. Sampath Kumar G. Venakata Narayana Synthesis and Characterization of Process-Related Impurities of Antihypertensive Drug Olmesartan Medoxomil Journal of Chemistry |
| title | Synthesis and Characterization of Process-Related Impurities of Antihypertensive Drug Olmesartan Medoxomil |
| title_full | Synthesis and Characterization of Process-Related Impurities of Antihypertensive Drug Olmesartan Medoxomil |
| title_fullStr | Synthesis and Characterization of Process-Related Impurities of Antihypertensive Drug Olmesartan Medoxomil |
| title_full_unstemmed | Synthesis and Characterization of Process-Related Impurities of Antihypertensive Drug Olmesartan Medoxomil |
| title_short | Synthesis and Characterization of Process-Related Impurities of Antihypertensive Drug Olmesartan Medoxomil |
| title_sort | synthesis and characterization of process related impurities of antihypertensive drug olmesartan medoxomil |
| url | http://dx.doi.org/10.1155/2013/516459 |
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