Specific cognitive deficits in preschool age correlated with qualitative and quantitative MRI parameters in prematurely born children
Background: Cognitive deficits after perinatal brain lesion in preterm infants are among the most common neurodevelopmental disturbances. The relationship between structural changes on at term magnetic resonance imaging (MRI) and cognitive deficits in the preschool age should be a special focus due...
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Elsevier
2020-04-01
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| Series: | Pediatrics and Neonatology |
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| author | Mirna Kostović Srzentić Marina Raguž David Ozretić |
| author_facet | Mirna Kostović Srzentić Marina Raguž David Ozretić |
| author_sort | Mirna Kostović Srzentić |
| collection | DOAJ |
| description | Background: Cognitive deficits after perinatal brain lesion in preterm infants are among the most common neurodevelopmental disturbances. The relationship between structural changes on at term magnetic resonance imaging (MRI) and cognitive deficits in the preschool age should be a special focus due to timely intervention. The aim of this study was to correlate qualitative and quantitative MRI parameters of perinatal brain lesion in preterm children, on early neonatal MRI and follow up MRI, with general and specific cognitive functions in the preschool age. Methods: Twenty-one preterm infants with verified perinatal lesions based on clinical and ultrasound data underwent a brain MRI at term-equivalent age and a second MRI between 3 and 5 years of age. Qualitative and quantitative MRI analyses were done. All subjects underwent cognitive assessment (3–5 years) using Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III) and Developmental Neuropsychological Assessment (NEPSY-II). Results: Results show that many structural changes on at term MRI and on follow up MRI in preterm born children moderately correlate with specific cognitive deficits in preschool age. At term equivalent MRI, white matter changes and cortical thickness correlate to general and specific cognitive functions in infants born preterm. By analyzing follow up MRI at preschool age, structural changes of different white matter segments, corpus callosum, cortical thickness and lobe volume correlate to some specific cognitive functions. Conclusion: Besides general cognitive delay, specific cognitive deficits in preterm children should be targeted in research and intervention, optimally combined with MRI scanning, providing timely and early intervention of cognitive deficits after perinatal brain lesion. Our results, as well as previously published results, suggest the importance of detailed preschool neuropsychological assessment, prior to enrolment in the school system. Although preliminary, our results expand our understanding of the relationship between early brain developmental lesions and cognitive outcome following premature birth. Key Words: cognitive deficit, MRI, perinatal lesion, premature infants, preschool age |
| format | Article |
| id | doaj-art-5752c01ebef9404c881d2b2610bb2334 |
| institution | Kabale University |
| issn | 1875-9572 |
| language | English |
| publishDate | 2020-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-5752c01ebef9404c881d2b2610bb23342025-08-20T03:26:24ZengElsevierPediatrics and Neonatology1875-95722020-04-0161216016710.1016/j.pedneo.2019.09.003Specific cognitive deficits in preschool age correlated with qualitative and quantitative MRI parameters in prematurely born childrenMirna Kostović Srzentić0Marina Raguž1David Ozretić2Department of Health Psychology, University of Applied Health Sciences, Zagreb, Croatia; Croatian Institute for Brain Research, Center of Research Excellence for Basic, Clinical and Translational Neuroscience, University of Zagreb, School of Medicine, Zagreb, Croatia; Corresponding author. University of Applied Health Sciences, Department of Health Psychology Mlinarska 38, 10000 Zagreb, Croatia.Croatian Institute for Brain Research, Center of Research Excellence for Basic, Clinical and Translational Neuroscience, University of Zagreb, School of Medicine, Zagreb, Croatia; Department of Neurosurgery, University Hospital Dubrava, Zagreb, CroatiaCroatian Institute for Brain Research, Center of Research Excellence for Basic, Clinical and Translational Neuroscience, University of Zagreb, School of Medicine, Zagreb, Croatia; Department of Radiology, University Hospital Centre Zagreb, Zagreb, CroatiaBackground: Cognitive deficits after perinatal brain lesion in preterm infants are among the most common neurodevelopmental disturbances. The relationship between structural changes on at term magnetic resonance imaging (MRI) and cognitive deficits in the preschool age should be a special focus due to timely intervention. The aim of this study was to correlate qualitative and quantitative MRI parameters of perinatal brain lesion in preterm children, on early neonatal MRI and follow up MRI, with general and specific cognitive functions in the preschool age. Methods: Twenty-one preterm infants with verified perinatal lesions based on clinical and ultrasound data underwent a brain MRI at term-equivalent age and a second MRI between 3 and 5 years of age. Qualitative and quantitative MRI analyses were done. All subjects underwent cognitive assessment (3–5 years) using Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III) and Developmental Neuropsychological Assessment (NEPSY-II). Results: Results show that many structural changes on at term MRI and on follow up MRI in preterm born children moderately correlate with specific cognitive deficits in preschool age. At term equivalent MRI, white matter changes and cortical thickness correlate to general and specific cognitive functions in infants born preterm. By analyzing follow up MRI at preschool age, structural changes of different white matter segments, corpus callosum, cortical thickness and lobe volume correlate to some specific cognitive functions. Conclusion: Besides general cognitive delay, specific cognitive deficits in preterm children should be targeted in research and intervention, optimally combined with MRI scanning, providing timely and early intervention of cognitive deficits after perinatal brain lesion. Our results, as well as previously published results, suggest the importance of detailed preschool neuropsychological assessment, prior to enrolment in the school system. Although preliminary, our results expand our understanding of the relationship between early brain developmental lesions and cognitive outcome following premature birth. Key Words: cognitive deficit, MRI, perinatal lesion, premature infants, preschool agehttp://www.sciencedirect.com/science/article/pii/S1875957219304991 |
| spellingShingle | Mirna Kostović Srzentić Marina Raguž David Ozretić Specific cognitive deficits in preschool age correlated with qualitative and quantitative MRI parameters in prematurely born children Pediatrics and Neonatology |
| title | Specific cognitive deficits in preschool age correlated with qualitative and quantitative MRI parameters in prematurely born children |
| title_full | Specific cognitive deficits in preschool age correlated with qualitative and quantitative MRI parameters in prematurely born children |
| title_fullStr | Specific cognitive deficits in preschool age correlated with qualitative and quantitative MRI parameters in prematurely born children |
| title_full_unstemmed | Specific cognitive deficits in preschool age correlated with qualitative and quantitative MRI parameters in prematurely born children |
| title_short | Specific cognitive deficits in preschool age correlated with qualitative and quantitative MRI parameters in prematurely born children |
| title_sort | specific cognitive deficits in preschool age correlated with qualitative and quantitative mri parameters in prematurely born children |
| url | http://www.sciencedirect.com/science/article/pii/S1875957219304991 |
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