B7-H3 and CSPG4 co-targeting as Pan-CAR-T cell treatment of triple-negative breast cancer

B7-H3 and CSPG4 co-targeting as Pan-CAR-T cell treatment of triple-negative breast cancer

Purpose Chimeric antigen receptor T (CAR-T) cell therapy is under clinical investigation in patients with metastatic triple-negative breast cancer (TNBC). However, the identification of targetable antigens remains a high priority to avoid toxicity and prevent tumor escape.Experimental design Here we...

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Bibliographic Details
Main Authors: Siobhán O’Connor, Barbara Savoldo, Gianpietro Dotti, Simone Stucchi, Roberto Borea, Susana Garcia-Recio, Manuela Zingarelli, Patrick D Rädler, Elena Camerini, Caroline Marnata Pellegry, H Shelton Earp, Lisa A Carey, Charles M Perou
Format: Article
Language:English
Published: BMJ Publishing Group 2025-05-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/5/e011533.full
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