Insights into the pharmaceutical properties of green fabricated Iron oxide nanoparticles
Abstract Researchers have recently grown interested in utilizing plant extracts as effective reducing agents for the eco-friendly synthesis of nanoparticles. The present investigation involved the preparation of Iraqi onion extract (Allium cepa), which was further utilized as a reducing agent for th...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-09327-x |
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| Summary: | Abstract Researchers have recently grown interested in utilizing plant extracts as effective reducing agents for the eco-friendly synthesis of nanoparticles. The present investigation involved the preparation of Iraqi onion extract (Allium cepa), which was further utilized as a reducing agent for the biosynthesis of Fe3O4-nanoparticles (NPs). Characterization of nanoparticles was conducted using UV-visible spectroscopy, TEM, XRD, FT-IR, FESEM, and EDS analyses. The in vitro cytotoxicity was assessed in MDCK-SIAT cells utilizing the MTT assay, while the antiviral efficacy was examined with the neuraminidase assay kit MAK12. Antibacterial efficacy was examined against S. aureus and E. coli utilizing a disk-diffusion methodology. The DPPH assay was employed to evaluate antioxidant activity. The impact of A. cepa extract and Fe3O4-NPs on phagocytic cell activity was evaluated. Our findings demonstrated the production of solid, crystalline, semi-spherical Fe3O4 measuring 36 ± 1.23 nm, exhibiting significant antibacterial, antiviral, and antioxidant properties. A. cepa extract and Fe3O4-NPs can augment the phagocytic activity of phagocytic cells by elevating the formation of reactive oxygen species. In conclusion, Onion peel extract is a superior option for synthesizing Fe3O4-NPs, which may be employed in many therapeutic applications in the future. |
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| ISSN: | 2045-2322 |