Association of Peripheral Monocyte Count with Soluble P-Selectin and Advanced Stages in Nasopharyngeal Carcinoma
Introduction. Inflammation is widely recognized to play an important role in cancer progression and is related to thrombosis. Soluble P-selectin (sP-selectin) is one of several biomarkers that may be predictive of thrombosis in cancer. This study aimed to investigate the correlation between monocyte...
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Wiley
2018-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2018/3864398 |
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| author | Adi Surya Komala Andhika Rachman |
| author_facet | Adi Surya Komala Andhika Rachman |
| author_sort | Adi Surya Komala |
| collection | DOAJ |
| description | Introduction. Inflammation is widely recognized to play an important role in cancer progression and is related to thrombosis. Soluble P-selectin (sP-selectin) is one of several biomarkers that may be predictive of thrombosis in cancer. This study aimed to investigate the correlation between monocyte count and sP-selectin in various stages of nasopharyngeal carcinoma. Methods. Fifty-five patients with nasopharyngeal carcinoma were divided into three groups according to nodal and distant metastasis (group of stages I-IVA, IVB, and IVC). Monocyte count was calculated from routine peripheral blood examination, while sP-selectin level was measured using commercial ELISA kit. Results. The monocyte count of subjects in groups IVB and IVC was significantly higher compared to group I-IVA (707/μL versus 528/μL, p=0.022; 841/μL versus 528/μL, p=0.005). Plasma levels of sP-selectin in group IVC were higher than group I-IVA (59.5 ng/mL versus 41.97 ng/mL, p=0.001) and group IVB (59.5 ng/mL versus 45.53 ng/mL, p=0.007). In subjects with high monocyte count (>665/μL), there was moderate correlation between monocyte count and sP-selectin (r=0.436, p=0.022). Conclusion. Advanced stages of nasopharyngeal carcinoma had higher levels of monocyte count and sP-selectin compared to earlier stages. Monocyte count was correlated with sP-selectin especially in high monocyte count subgroup. |
| format | Article |
| id | doaj-art-574936eb82964f3aa43ac2c970ca840c |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-574936eb82964f3aa43ac2c970ca840c2025-02-03T05:54:25ZengWileyAdvances in Hematology1687-91041687-91122018-01-01201810.1155/2018/38643983864398Association of Peripheral Monocyte Count with Soluble P-Selectin and Advanced Stages in Nasopharyngeal CarcinomaAdi Surya Komala0Andhika Rachman1Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Central Jakarta 10430, IndonesiaInternal Medicine Department, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Central Jakarta 10430, IndonesiaIntroduction. Inflammation is widely recognized to play an important role in cancer progression and is related to thrombosis. Soluble P-selectin (sP-selectin) is one of several biomarkers that may be predictive of thrombosis in cancer. This study aimed to investigate the correlation between monocyte count and sP-selectin in various stages of nasopharyngeal carcinoma. Methods. Fifty-five patients with nasopharyngeal carcinoma were divided into three groups according to nodal and distant metastasis (group of stages I-IVA, IVB, and IVC). Monocyte count was calculated from routine peripheral blood examination, while sP-selectin level was measured using commercial ELISA kit. Results. The monocyte count of subjects in groups IVB and IVC was significantly higher compared to group I-IVA (707/μL versus 528/μL, p=0.022; 841/μL versus 528/μL, p=0.005). Plasma levels of sP-selectin in group IVC were higher than group I-IVA (59.5 ng/mL versus 41.97 ng/mL, p=0.001) and group IVB (59.5 ng/mL versus 45.53 ng/mL, p=0.007). In subjects with high monocyte count (>665/μL), there was moderate correlation between monocyte count and sP-selectin (r=0.436, p=0.022). Conclusion. Advanced stages of nasopharyngeal carcinoma had higher levels of monocyte count and sP-selectin compared to earlier stages. Monocyte count was correlated with sP-selectin especially in high monocyte count subgroup.http://dx.doi.org/10.1155/2018/3864398 |
| spellingShingle | Adi Surya Komala Andhika Rachman Association of Peripheral Monocyte Count with Soluble P-Selectin and Advanced Stages in Nasopharyngeal Carcinoma Advances in Hematology |
| title | Association of Peripheral Monocyte Count with Soluble P-Selectin and Advanced Stages in Nasopharyngeal Carcinoma |
| title_full | Association of Peripheral Monocyte Count with Soluble P-Selectin and Advanced Stages in Nasopharyngeal Carcinoma |
| title_fullStr | Association of Peripheral Monocyte Count with Soluble P-Selectin and Advanced Stages in Nasopharyngeal Carcinoma |
| title_full_unstemmed | Association of Peripheral Monocyte Count with Soluble P-Selectin and Advanced Stages in Nasopharyngeal Carcinoma |
| title_short | Association of Peripheral Monocyte Count with Soluble P-Selectin and Advanced Stages in Nasopharyngeal Carcinoma |
| title_sort | association of peripheral monocyte count with soluble p selectin and advanced stages in nasopharyngeal carcinoma |
| url | http://dx.doi.org/10.1155/2018/3864398 |
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