Comparison of [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/MRI in the Preoperative Diagnosis of Gastric Cancer
Purpose. Our objective was to compare the value of positron emission tomography/magnetic resonance imaging (PET/MRI) with the new imaging agent [68Ga]Ga-DOTA-FAPI-04 and the traditional imaging agent [18F]FDG for the preoperative diagnosis of gastric cancer. Methods. Forty patients with gastric canc...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
|
| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2023/6351330 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832546730617339904 |
|---|---|
| author | Tao Du Shun Zhang Xi-Mao Cui Ren-Hao Hu Hai-Yan Wang Jian-Juan Jiang Jun Zhao Lan Zhong Xiao-Hua Jiang |
| author_facet | Tao Du Shun Zhang Xi-Mao Cui Ren-Hao Hu Hai-Yan Wang Jian-Juan Jiang Jun Zhao Lan Zhong Xiao-Hua Jiang |
| author_sort | Tao Du |
| collection | DOAJ |
| description | Purpose. Our objective was to compare the value of positron emission tomography/magnetic resonance imaging (PET/MRI) with the new imaging agent [68Ga]Ga-DOTA-FAPI-04 and the traditional imaging agent [18F]FDG for the preoperative diagnosis of gastric cancer. Methods. Forty patients with gastric cancer diagnosed by gastroscopy in gastrointestinal surgery at our hospital from June 2020 to January 2021 were analyzed. All patients underwent simultaneous [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/MRI. The standard uptake value (SUV), fat removal standard uptake value (SUL), and diagnostic sensitivity, specificity, and accuracy for primary and metastatic lesions were compared, and their diagnostic value for different lymph node dissection stages was analyzed. Results. The median age of the patients in this cohort was 68 years. Twenty-nine patients underwent surgery, and 11 patients underwent gastroscopic biopsy. The SUVmax of primary lesions in the FDG group and the FAPI group was 5.74 ± 5.09 and 8.06 ± 4.88, respectively (P<0.01); SULmax values were 3.52 ± 2.80 and 5.64 ± 3.25, respectively (P<0.01). The SUVmax of metastases in the two groups was 3.81 ± 3.08 and 5.17 ± 2.80, respectively (P<0.05). The diagnostic sensitivities for primary lesions in the FDG group and the FAPI group were 0.72 and 0.94, respectively (P<0.05). Combined with postoperative pathological staging, there was no difference in diagnostic sensitivity and specificity of lymph node staging between the FDG and FAPI groups (P>0.05). Conclusion. Compared with the traditional imaging agent, [68Ga]Ga-DOTA-FAPI-04 has better diagnostic efficiency but no substantial advantage for preoperative lymph node staging. |
| format | Article |
| id | doaj-art-5743db7929e04448b2f9f3e113a60a80 |
| institution | Kabale University |
| issn | 2291-2797 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-5743db7929e04448b2f9f3e113a60a802025-02-03T06:47:15ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27972023-01-01202310.1155/2023/6351330Comparison of [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/MRI in the Preoperative Diagnosis of Gastric CancerTao Du0Shun Zhang1Xi-Mao Cui2Ren-Hao Hu3Hai-Yan Wang4Jian-Juan Jiang5Jun Zhao6Lan Zhong7Xiao-Hua Jiang8Department of Gastrointestinal SurgeryDepartment of Gastrointestinal SurgeryDepartment of Gastrointestinal SurgeryDepartment of Gastrointestinal SurgeryDepartment of Nuclear MedicineDepartment of Nuclear MedicineDepartment of Nuclear MedicineDepartment of Digestive MedicineDepartment of Gastrointestinal SurgeryPurpose. Our objective was to compare the value of positron emission tomography/magnetic resonance imaging (PET/MRI) with the new imaging agent [68Ga]Ga-DOTA-FAPI-04 and the traditional imaging agent [18F]FDG for the preoperative diagnosis of gastric cancer. Methods. Forty patients with gastric cancer diagnosed by gastroscopy in gastrointestinal surgery at our hospital from June 2020 to January 2021 were analyzed. All patients underwent simultaneous [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/MRI. The standard uptake value (SUV), fat removal standard uptake value (SUL), and diagnostic sensitivity, specificity, and accuracy for primary and metastatic lesions were compared, and their diagnostic value for different lymph node dissection stages was analyzed. Results. The median age of the patients in this cohort was 68 years. Twenty-nine patients underwent surgery, and 11 patients underwent gastroscopic biopsy. The SUVmax of primary lesions in the FDG group and the FAPI group was 5.74 ± 5.09 and 8.06 ± 4.88, respectively (P<0.01); SULmax values were 3.52 ± 2.80 and 5.64 ± 3.25, respectively (P<0.01). The SUVmax of metastases in the two groups was 3.81 ± 3.08 and 5.17 ± 2.80, respectively (P<0.05). The diagnostic sensitivities for primary lesions in the FDG group and the FAPI group were 0.72 and 0.94, respectively (P<0.05). Combined with postoperative pathological staging, there was no difference in diagnostic sensitivity and specificity of lymph node staging between the FDG and FAPI groups (P>0.05). Conclusion. Compared with the traditional imaging agent, [68Ga]Ga-DOTA-FAPI-04 has better diagnostic efficiency but no substantial advantage for preoperative lymph node staging.http://dx.doi.org/10.1155/2023/6351330 |
| spellingShingle | Tao Du Shun Zhang Xi-Mao Cui Ren-Hao Hu Hai-Yan Wang Jian-Juan Jiang Jun Zhao Lan Zhong Xiao-Hua Jiang Comparison of [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/MRI in the Preoperative Diagnosis of Gastric Cancer Canadian Journal of Gastroenterology and Hepatology |
| title | Comparison of [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/MRI in the Preoperative Diagnosis of Gastric Cancer |
| title_full | Comparison of [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/MRI in the Preoperative Diagnosis of Gastric Cancer |
| title_fullStr | Comparison of [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/MRI in the Preoperative Diagnosis of Gastric Cancer |
| title_full_unstemmed | Comparison of [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/MRI in the Preoperative Diagnosis of Gastric Cancer |
| title_short | Comparison of [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/MRI in the Preoperative Diagnosis of Gastric Cancer |
| title_sort | comparison of 68ga ga dota fapi 04 and 18f fdg pet mri in the preoperative diagnosis of gastric cancer |
| url | http://dx.doi.org/10.1155/2023/6351330 |
| work_keys_str_mv | AT taodu comparisonof68gagadotafapi04and18ffdgpetmriinthepreoperativediagnosisofgastriccancer AT shunzhang comparisonof68gagadotafapi04and18ffdgpetmriinthepreoperativediagnosisofgastriccancer AT ximaocui comparisonof68gagadotafapi04and18ffdgpetmriinthepreoperativediagnosisofgastriccancer AT renhaohu comparisonof68gagadotafapi04and18ffdgpetmriinthepreoperativediagnosisofgastriccancer AT haiyanwang comparisonof68gagadotafapi04and18ffdgpetmriinthepreoperativediagnosisofgastriccancer AT jianjuanjiang comparisonof68gagadotafapi04and18ffdgpetmriinthepreoperativediagnosisofgastriccancer AT junzhao comparisonof68gagadotafapi04and18ffdgpetmriinthepreoperativediagnosisofgastriccancer AT lanzhong comparisonof68gagadotafapi04and18ffdgpetmriinthepreoperativediagnosisofgastriccancer AT xiaohuajiang comparisonof68gagadotafapi04and18ffdgpetmriinthepreoperativediagnosisofgastriccancer |