SPECIFIC METABOLISM OF BLOOD AMINO-ACIDS IN RESPIRATORY DISTRESS SYNDROME OF THE NEWBORNS
Respiratory distress syndrome of the newborns is one of the most common critical states of the neonatal period, the cause of this complication is the primary deficiency of surfactant with the consequent progress of hypoxia, syndrome of fetal systemic inflammatory response and hypermetabolism. Goal of ...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2017-11-01
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| Series: | Вестник анестезиологии и реаниматологии |
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| Online Access: | https://www.vair-journal.com/jour/article/view/40 |
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| author | P. I. Mironov I. Z. Gareev Yu. S. Аleksandrovich K. V. Pshenisnov |
| author_facet | P. I. Mironov I. Z. Gareev Yu. S. Аleksandrovich K. V. Pshenisnov |
| author_sort | P. I. Mironov |
| collection | DOAJ |
| description | Respiratory distress syndrome of the newborns is one of the most common critical states of the neonatal period, the cause of this complication is the primary deficiency of surfactant with the consequent progress of hypoxia, syndrome of fetal systemic inflammatory response and hypermetabolism. Goal of the trial: the evaluation of blood amino-acid metabolism in the newborns with respiratory distress syndrome depending on the duration of artificial pulmonary ventilation. Materials and methods: prospective controlled non-randomized one-centered trials with 48 newborns included. The main group (n = 22) included newborns to whom surfactant was administered one, and the control group (n = 26) included children who required the repeated administration of surfactant and continuous (72 hours and more) artificial pulmonary ventilation. Results of the trial. It has been found out that the children from the control group had higher concentration of citrulline in blood plasma (21.0 ± 0.7 versus 14.4 ± 1.2, p < 0.05) and lower concentration of the total protein in blood plasma (49.10 ± 0.87 versus 64.8 ± 1.8; p < 0.05). The negative correlation dependency was found between hypoproteinemia and content of alanine (r = -0.99; p < 0.05), arginine (r = -0.97; p < 0.005), citrulline (r = -0.93; p < 0.05) and tyrosine (r = -0.66; p < 0.05). Conclusion. Severe course of respiratory distress syndrome in the newborns is accompanied by obvious disorders in amino acid metabolism, which requires timely management. |
| format | Article |
| id | doaj-art-57420138dfef4403b44547ed715e6734 |
| institution | DOAJ |
| issn | 2078-5658 2541-8653 |
| language | Russian |
| publishDate | 2017-11-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Вестник анестезиологии и реаниматологии |
| spelling | doaj-art-57420138dfef4403b44547ed715e67342025-08-20T03:23:11ZrusNew Terra Publishing HouseВестник анестезиологии и реаниматологии2078-56582541-86532017-11-01124394310.21292/2078-5658-2015-12-4-39-4340SPECIFIC METABOLISM OF BLOOD AMINO-ACIDS IN RESPIRATORY DISTRESS SYNDROME OF THE NEWBORNSP. I. Mironov0I. Z. Gareev1Yu. S. Аleksandrovich2K. V. Pshenisnov3Bashkirsky State Medical University, UfaRepublican Children Clinical Hospital, UfaSt. Petersburg State Pediatric Medical University, St. PetersburgSt. Petersburg State Pediatric Medical University, St. PetersburgRespiratory distress syndrome of the newborns is one of the most common critical states of the neonatal period, the cause of this complication is the primary deficiency of surfactant with the consequent progress of hypoxia, syndrome of fetal systemic inflammatory response and hypermetabolism. Goal of the trial: the evaluation of blood amino-acid metabolism in the newborns with respiratory distress syndrome depending on the duration of artificial pulmonary ventilation. Materials and methods: prospective controlled non-randomized one-centered trials with 48 newborns included. The main group (n = 22) included newborns to whom surfactant was administered one, and the control group (n = 26) included children who required the repeated administration of surfactant and continuous (72 hours and more) artificial pulmonary ventilation. Results of the trial. It has been found out that the children from the control group had higher concentration of citrulline in blood plasma (21.0 ± 0.7 versus 14.4 ± 1.2, p < 0.05) and lower concentration of the total protein in blood plasma (49.10 ± 0.87 versus 64.8 ± 1.8; p < 0.05). The negative correlation dependency was found between hypoproteinemia and content of alanine (r = -0.99; p < 0.05), arginine (r = -0.97; p < 0.005), citrulline (r = -0.93; p < 0.05) and tyrosine (r = -0.66; p < 0.05). Conclusion. Severe course of respiratory distress syndrome in the newborns is accompanied by obvious disorders in amino acid metabolism, which requires timely management.https://www.vair-journal.com/jour/article/view/40newbornsrespiratory distress syndromemetabolismanimo-acids |
| spellingShingle | P. I. Mironov I. Z. Gareev Yu. S. Аleksandrovich K. V. Pshenisnov SPECIFIC METABOLISM OF BLOOD AMINO-ACIDS IN RESPIRATORY DISTRESS SYNDROME OF THE NEWBORNS Вестник анестезиологии и реаниматологии newborns respiratory distress syndrome metabolism animo-acids |
| title | SPECIFIC METABOLISM OF BLOOD AMINO-ACIDS IN RESPIRATORY DISTRESS SYNDROME OF THE NEWBORNS |
| title_full | SPECIFIC METABOLISM OF BLOOD AMINO-ACIDS IN RESPIRATORY DISTRESS SYNDROME OF THE NEWBORNS |
| title_fullStr | SPECIFIC METABOLISM OF BLOOD AMINO-ACIDS IN RESPIRATORY DISTRESS SYNDROME OF THE NEWBORNS |
| title_full_unstemmed | SPECIFIC METABOLISM OF BLOOD AMINO-ACIDS IN RESPIRATORY DISTRESS SYNDROME OF THE NEWBORNS |
| title_short | SPECIFIC METABOLISM OF BLOOD AMINO-ACIDS IN RESPIRATORY DISTRESS SYNDROME OF THE NEWBORNS |
| title_sort | specific metabolism of blood amino acids in respiratory distress syndrome of the newborns |
| topic | newborns respiratory distress syndrome metabolism animo-acids |
| url | https://www.vair-journal.com/jour/article/view/40 |
| work_keys_str_mv | AT pimironov specificmetabolismofbloodaminoacidsinrespiratorydistresssyndromeofthenewborns AT izgareev specificmetabolismofbloodaminoacidsinrespiratorydistresssyndromeofthenewborns AT yusaleksandrovich specificmetabolismofbloodaminoacidsinrespiratorydistresssyndromeofthenewborns AT kvpshenisnov specificmetabolismofbloodaminoacidsinrespiratorydistresssyndromeofthenewborns |