Analysis of the correlation between cognitive impairment and non-traditional risk factors in maintenance hemodialysis patients
Objective To evaluate the incidence of cognitive impairment(CI) and the correlation between CI and non- traditional risk factors among maintenance hemodialysis(MHD) patients.Methods 140 MHD patients were surveyed in this study.The Montreal cognitive assessment scale(MoCA) was used to make cognitive...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2015-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57920737&Fpath=home&index=0 |
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| Summary: | Objective To evaluate the incidence of cognitive impairment(CI) and the correlation between CI and non- traditional risk factors among maintenance hemodialysis(MHD) patients.Methods 140 MHD patients were surveyed in this study.The Montreal cognitive assessment scale(MoCA) was used to make cognitive function score.Cross-sectional survey of age,gender,years of education,disease and complications was done.High sensitivity c-reactive protein(hs-CRP),albumin,homocysteine(Hcy),and hemoglobin were assayed.The patients were then assigned into the CI group or the CI-free groups.The clinical and laboratory data were compared between the two groups.Results CI was detected in 80 patients(57.1%).In the CI group,the score of MoCA was(18.70 ± 2.74),the morbidity of combined diabetic nephropathy was 41.3%,hs-CRP was(13.6 ± 7.6) mg/L,and Hcy was(29.6 ± 6.2) μmol/L.Patients with CI had a significantly higher ratio of age>60,longer period of hemodialysis,higher morbidity of combined diabetic nephropathy and hypertension,and higher level of hs-CRP and Hcy(P<0.05).The education years,hemoglobin and albumin level were significantly lower in the CI group(P<0.05).Logistic regression analysis revealed that age,diabetic nephropathy,hemoglobin,Hcy,and hs-CRP were independent risk factors for CIO.Conclusions The incidence of CI in MHD patients is similar to that reported form other countries.Inflammation,homocysteine and anemia as non-traditional risk factors were relevant with the CI in MHD patients. |
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| ISSN: | 1671-2390 |