Molecular basis of ligand binding and receptor activation at the human A3 adenosine receptor

Molecular basis of ligand binding and receptor activation at the human A3 adenosine receptor

Abstract Adenosine receptors (ARs: A1AR, A2AAR, A2BAR, and A3AR) are crucial therapeutic targets; however, developing selective, efficacious drugs for them remains a significant challenge. Here, we present high-resolution cryo-electron microscopy (cryo-EM) structures of the human A3AR in three disti...

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Main Authors: Liudi Zhang, Jesse I. Mobbs, Felix M. Bennetts, Hariprasad Venugopal, Anh T. N. Nguyen, Arthur Christopoulos, Daan van der Es, Laura H. Heitman, Lauren T. May, Alisa Glukhova, David M. Thal
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62872-x
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