Neopterin inhibits ATP-induced calcium release in alveolar epithelial cells in vitro
Background: Serum neopterin concentrations rise during activation of the cellular immune system. It is suggested that neopterin interacts with cellular redox mechanisms. This induces oxidative stress, which inhibits intracellular Ca2+ transients in various cell types. In type II alveolar epithelial...
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| Format: | Article |
| Language: | English |
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Wiley
2002-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09622935020138217 |
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| _version_ | 1832549513011658752 |
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| author | Georg Hoffmann Frank Gollnick Rainer Meyer |
| author_facet | Georg Hoffmann Frank Gollnick Rainer Meyer |
| author_sort | Georg Hoffmann |
| collection | DOAJ |
| description | Background: Serum neopterin concentrations rise during activation of the cellular immune system. It is suggested that neopterin interacts with cellular redox mechanisms. This induces oxidative stress, which inhibits intracellular Ca2+ transients in various cell types. In type II alveolar epithelial cells, Ca2+ increase is considered involved in the exocytosis of surfactants. This exocytosis is disturbed during inflammation. |
| format | Article |
| id | doaj-art-572e987bcb6a45ffa4f9d63c4cae06b0 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2002-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-572e987bcb6a45ffa4f9d63c4cae06b02025-02-03T06:11:07ZengWileyMediators of Inflammation0962-93511466-18612002-01-0111318118510.1080/09622935020138217Neopterin inhibits ATP-induced calcium release in alveolar epithelial cells in vitroGeorg Hoffmann0Frank Gollnick1Rainer Meyer2Department of Physiology I, University of Bonn, Nussallee 11, Bonn 53111, GermanyDepartment of Physiology II, University of Bonn, Nussallee 11, Bonn 53111, GermanyDepartment of Physiology II, University of Bonn, Nussallee 11, Bonn 53111, GermanyBackground: Serum neopterin concentrations rise during activation of the cellular immune system. It is suggested that neopterin interacts with cellular redox mechanisms. This induces oxidative stress, which inhibits intracellular Ca2+ transients in various cell types. In type II alveolar epithelial cells, Ca2+ increase is considered involved in the exocytosis of surfactants. This exocytosis is disturbed during inflammation.http://dx.doi.org/10.1080/09622935020138217 |
| spellingShingle | Georg Hoffmann Frank Gollnick Rainer Meyer Neopterin inhibits ATP-induced calcium release in alveolar epithelial cells in vitro Mediators of Inflammation |
| title | Neopterin inhibits ATP-induced calcium release in alveolar epithelial cells in vitro |
| title_full | Neopterin inhibits ATP-induced calcium release in alveolar epithelial cells in vitro |
| title_fullStr | Neopterin inhibits ATP-induced calcium release in alveolar epithelial cells in vitro |
| title_full_unstemmed | Neopterin inhibits ATP-induced calcium release in alveolar epithelial cells in vitro |
| title_short | Neopterin inhibits ATP-induced calcium release in alveolar epithelial cells in vitro |
| title_sort | neopterin inhibits atp induced calcium release in alveolar epithelial cells in vitro |
| url | http://dx.doi.org/10.1080/09622935020138217 |
| work_keys_str_mv | AT georghoffmann neopterininhibitsatpinducedcalciumreleaseinalveolarepithelialcellsinvitro AT frankgollnick neopterininhibitsatpinducedcalciumreleaseinalveolarepithelialcellsinvitro AT rainermeyer neopterininhibitsatpinducedcalciumreleaseinalveolarepithelialcellsinvitro |