Alternative splicing induces sample-level variation in gene–gene correlations

Alternative splicing induces sample-level variation in gene–gene correlations

Abstract Background The vast majority of genes in the genome are multi-exonic, and are alternatively spliced during transcription, resulting in multiple isoforms for each gene. For some genes, different mRNA isoforms may have differential expression levels or be involved in different pathways. Bulk...

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Bibliographic Details
Main Authors: Yihao Lu, Brandon L. Pierce, Pei Wang, Fan Yang, Lin S. Chen
Format: Article
Language:English
Published: BMC 2024-12-01
Series:BMC Genomics
Subjects:
Alternative splicing
Total expression
Isoform
Gene–gene correlation
Sample-level variation
Online Access:https://doi.org/10.1186/s12864-024-11118-z
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