Emerging Biomarkers and Innovative Therapeutic Strategies in Diabetic Kidney Disease: A Pathway to Precision Medicine
Diabetes mellitus (DM) has emerged as the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) globally in recent years. Diabetic nephropathy (DN), or diabetic kidney disease (DKD) that occurs as a direct consequence of DM, has complex pathophysiological mechanisms, s...
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MDPI AG
2025-04-01
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| Series: | Diagnostics |
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| author | Sahana Shetty Renuka Suvarna Avivar Awasthi Mohan V. Bhojaraja Joseph M. Pappachan |
| author_facet | Sahana Shetty Renuka Suvarna Avivar Awasthi Mohan V. Bhojaraja Joseph M. Pappachan |
| author_sort | Sahana Shetty |
| collection | DOAJ |
| description | Diabetes mellitus (DM) has emerged as the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) globally in recent years. Diabetic nephropathy (DN), or diabetic kidney disease (DKD) that occurs as a direct consequence of DM, has complex pathophysiological mechanisms, such as various inflammatory processes and genetic and epigenetic factors, often accentuated by comorbid illnesses like hypertension and dyslipidemia. Therefore, management of DKD involves targeting these etio-pathological processes. Various medications with remarkable disease modifying properties have been introduced for treatment of DN in recent years. We update the current and future diagnostic and therapeutic landscapes against DKD in this article. |
| format | Article |
| id | doaj-art-571a1bf50fa74270b63f0701489e62f5 |
| institution | OA Journals |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-571a1bf50fa74270b63f0701489e62f52025-08-20T02:28:33ZengMDPI AGDiagnostics2075-44182025-04-0115897310.3390/diagnostics15080973Emerging Biomarkers and Innovative Therapeutic Strategies in Diabetic Kidney Disease: A Pathway to Precision MedicineSahana Shetty0Renuka Suvarna1Avivar Awasthi2Mohan V. Bhojaraja3Joseph M. Pappachan4Department of Endocrinology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal 576104, IndiaDepartment of Endocrinology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal 576104, IndiaDepartment of Endocrinology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal 576104, IndiaDepartment of Nephrology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal 576104, IndiaDepartment of Endocrinology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal 576104, IndiaDiabetes mellitus (DM) has emerged as the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) globally in recent years. Diabetic nephropathy (DN), or diabetic kidney disease (DKD) that occurs as a direct consequence of DM, has complex pathophysiological mechanisms, such as various inflammatory processes and genetic and epigenetic factors, often accentuated by comorbid illnesses like hypertension and dyslipidemia. Therefore, management of DKD involves targeting these etio-pathological processes. Various medications with remarkable disease modifying properties have been introduced for treatment of DN in recent years. We update the current and future diagnostic and therapeutic landscapes against DKD in this article.https://www.mdpi.com/2075-4418/15/8/973diabetic kidney diseasediabetic nephropathydiabetesbiomarkerstherapeutic strategies |
| spellingShingle | Sahana Shetty Renuka Suvarna Avivar Awasthi Mohan V. Bhojaraja Joseph M. Pappachan Emerging Biomarkers and Innovative Therapeutic Strategies in Diabetic Kidney Disease: A Pathway to Precision Medicine Diagnostics diabetic kidney disease diabetic nephropathy diabetes biomarkers therapeutic strategies |
| title | Emerging Biomarkers and Innovative Therapeutic Strategies in Diabetic Kidney Disease: A Pathway to Precision Medicine |
| title_full | Emerging Biomarkers and Innovative Therapeutic Strategies in Diabetic Kidney Disease: A Pathway to Precision Medicine |
| title_fullStr | Emerging Biomarkers and Innovative Therapeutic Strategies in Diabetic Kidney Disease: A Pathway to Precision Medicine |
| title_full_unstemmed | Emerging Biomarkers and Innovative Therapeutic Strategies in Diabetic Kidney Disease: A Pathway to Precision Medicine |
| title_short | Emerging Biomarkers and Innovative Therapeutic Strategies in Diabetic Kidney Disease: A Pathway to Precision Medicine |
| title_sort | emerging biomarkers and innovative therapeutic strategies in diabetic kidney disease a pathway to precision medicine |
| topic | diabetic kidney disease diabetic nephropathy diabetes biomarkers therapeutic strategies |
| url | https://www.mdpi.com/2075-4418/15/8/973 |
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